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Age, but not amyloidosis, induced changes in global levels of histone modifications in susceptible and disease-resistant neurons in Alzheimer's disease model mice

Citation

Dyer, M and Phipps, AJ and Mitew, S and Taberlay, PC and Woodhouse, A, Age, but not amyloidosis, induced changes in global levels of histone modifications in susceptible and disease-resistant neurons in Alzheimer's disease model mice, Frontiers in Aging Neuroscience, 11 Article 68. ISSN 1663-4365 (2019) [Refereed Article]


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Copyright Statement

Copyright 2019 Dyer, Phipps, Mitew, Taberlay and Woodhouse. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fnagi.2019.00068

Abstract

There is increasing interest in the role of epigenetic alterations in Alzheimer's disease (AD). The epigenome of every cell type is distinct, yet data regarding epigenetic change in specific cell types in aging and AD is limited. We investigated histone tail modifications in neuronal subtypes in wild-type and APP/PS1 mice at 3 (pre-pathology), 6 (pathology-onset) and 12 (pathology-rich) months of age. In neurofilament (NF)-positive pyramidal neurons (vulnerable to AD pathology), and in calretinin-labeled interneurons (resistant to AD pathology) there were no global alterations in histone 3 lysine 4 trimethylation (H3K4me3), histone 3 lysine 27 acetylation (H3K27ac) or histone 3 lysine 27 trimethylation (H3K27me3) in APP/PS1 compared to wild-type mice at any age. Interestingly, age-related changes in the presence of H3K27ac and H3K27me3 were detected in NF-labeled pyramidal neurons and calretinin-positive interneurons, respectively. These data suggest that the global levels of histone modifications change with age, whilst amyloid plaque deposition and its sequelae do not result in global alterations of H3K4me3, H3K27ac and H3K27me3 in NF-positive pyramidal neurons or calretinin-labeled interneurons.

Item Details

Item Type:Refereed Article
Keywords:epigenetics, H3K4me3, H4K27ac, H3K27me3, calretinin, neurofilament triplet proteins
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
UTAS Author:Dyer, M (Mr Marcus Dyer)
UTAS Author:Phipps, AJ (Mr Andrew Phipps)
UTAS Author:Taberlay, PC (Dr Phillippa Taberlay)
UTAS Author:Woodhouse, A (Dr Adele Woodhouse)
ID Code:133062
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-06-05
Last Modified:2019-07-23
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