Vahamurto, L and Pahkala, K and Magnussen, CG and Hutri-Kahonen, N and Kahonen, M and Laitinen, T and Taittonen, L and Tossavainen, P and Lehtimaki, T and Jokinen, E and Telama, R and Ronnemaa, T and Viikari, J and Juonala, M and Raitakari, OT, Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in Young Finns study, Atherosclerosis, 280 pp. 92-98. ISSN 0021-9150 (2019) [Refereed Article]
© 2018 Published by Elsevier B.V.
Methods: The study population included 2063 participants of the Cardiovascular Risk in Young Finns Study, born during the period 1962-1977, with risk factor data available from baseline (1980) when participants were aged 3-18 years, and had risk factor data collected again in adulthood (2011) when aged 34-49 years.
Results: Adult CHD risk factor profile was similar for those who resided in eastern or western Finland in childhood. Over life-course from 1980 to 2011, those subjects with childhood residency in eastern Finland had, on average, higher systolic (p = 0.006) and diastolic (p = 0.0009) blood pressures, total (p = 0.01) and LDL-cholesterol (p = 0.01), triglycerides (p = 0.04), apoB (p = 0.02), and serum glucose (p < 0.0001) than those who resided in western Finland in childhood.
Conclusions: Our sample of adult Finns aged 34-49 years had a similar CHD risk factor profile irrespective of whether they resided in eastern or western Finland during their childhood. However, when considering participants risk factor profiles over a 31-year period, those who resided in eastern Finland in childhood were associated with a less favorable CHD risk factor profile than those who resided in western Finland in childhood. The observed differences suggest that future CHD mortality might remain higher in eastern Finland compared with western Finland.
|Item Type:||Refereed Article|
|Keywords:||adulthood, atherosclerosis precursors, cardiovascular disease, longitudinal, population, risk factors|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Magnussen, CG (Dr Costan Magnussen)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
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