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The emerging role of voltage-gated sodium channels in tumor biology

Citation

Mao, W and Zhang, J and Korner, H and Jiang, Y and Ying, S, The emerging role of voltage-gated sodium channels in tumor biology, Frontiers in Oncology, 9, (March) Article 124. ISSN 2234-943X (2019) [Refereed Article]


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Copyright 2019 Mao, Zhang, Korner, Jiang and Ying. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fonc.2019.00124

Abstract

Voltage-gated sodium channels (VGSCs) are transmembrane proteins which function as gates that control the flux of ions across the cell membrane. They are key ion channels for action potentials in excitable tissues and have important physiological functions. Abnormal function of VGSCs will lead to dysfunction of the body and trigger a variety of diseases. Various studies have demonstrated the participation of VGSCs in the progression of different tumors, such as prostate cancer, cervical cancer, breast cancer, and others, linking VGSC to the invasive capacity of tumor cells. However, it is still unclear whether the VGSC regulate the malignant biological behavior of tumors. Therefore, this paper systematically addresses the latest research progress on VGSCs subunits and tumors and the underlying mechanisms, and it summarizes the potential of VGSCs subunits to serve as potential targets for tumor diagnosis and treatment.

Item Details

Item Type:Refereed Article
Keywords:VGSCs, expression regulation, mechanism, metastasis, tumors
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
UTAS Author:Korner, H (Professor Heinrich Korner)
ID Code:133057
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-06-05
Last Modified:2019-07-23
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