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A need for better understanding is the major determinant for public perceptions of human gene editing

Citation

McCaughey, T and Budden, DM and Sanfilippo, PG and Gooden, GEC and Fan, L and Fenwick, E and Rees, G and Macgregor, C and Si, L and Chen, C and Liang, HH and Pebay, A and Baldwin, T and Hewitt, AW, A need for better understanding is the major determinant for public perceptions of human gene editing, Human Gene Therapy, 30, (1) pp. 36-43. ISSN 1043-0342 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Mary Ann Liebert, Inc.

DOI: doi:10.1089/hum.2018.033

Abstract

The CRISPR/Cas system could provide an efficient and reliable means of editing the human genome and has the potential to revolutionize modern medicine; however, rapid developments are raising complex ethical issues. There has been significant scientific debate regarding the acceptability of some applications of CRISPR/Cas, with leaders in the field highlighting the need for the lay public's views to shape expert discussion. As such, we sought to determine the factors that influence public opinion on gene editing. We created a 17-item online survey translated into 11 languages and advertised worldwide. Topic modeling was used to analyze textual responses to determine what factors influenced respondents' opinions toward human somatic or embryonic gene editing, and how this varied among respondents with differing attitudes and demographic backgrounds. A total of 3,988 free-text responses were analyzed. Respondents had a mean age of 32 (range, 11-90) years, and 37% were female. The most prevalent topics cited were Future Generations, Research, Human Editing, Children, and Health. Respondents who disagreed with gene editing for health-related purposes were more likely to cite the topic Better Understanding than those who agreed to both somatic and embryonic gene editing. Respondents from Western backgrounds more frequently discussed Future Generations, compared with participants from Eastern countries. Religious respondents did not cite the topic Religious Beliefs more frequently than did nonreligious respondents, whereas Christian respondents were more likely to cite the topic Future Generations. Our results suggest that public resistance to human somatic or embryonic gene editing does not stem from an inherent mistrust of genome modification, but rather a desire for greater understanding. Furthermore, we demonstrate that factors influencing public opinion vary greatly amongst demographic groups. It is crucial that the determinants of public attitudes toward CRISPR/Cas be well understood so that the technology does not suffer the negative public sentiment seen with previous genetic biotechnologies.

Item Details

Item Type:Refereed Article
Keywords:CRISPR/Cas, gene editing, global survey, public perception, text mining
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genome Structure and Regulation
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Inherited Diseases (incl. Gene Therapy)
UTAS Author:Si, L (Mr Lei Si)
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
ID Code:133003
Year Published:2019
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-05-30
Last Modified:2019-07-02
Downloads:0

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