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Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS


Simpson Jr, S and Taylor, KL and Jelinek, GA and De Livera, AM and Brown, CR and O'Kearney, E and Neate, SL and Bevens, W and Weiland, TJ, Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS, Multiple Sclerosis and Related Disorders, 30 pp. 165-175. ISSN 2211-0348 (2019) [Refereed Article]


Copyright Statement

Copyright 2019 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

DOI: doi:10.1016/j.msard.2019.02.014


Background: Depression is highly prevalent among people with MS, and determinants thereof would be useful.

Objectives: We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS.

Methods: Positive depression-screen assessed by Patient Health Questionnaire (PHQ)-2 and PHQ-9. Associations of demographic and clinical factors with depression-screen and change thereof assessed using multivariable regression models, adjusted for age, sex, disability, fatigue, antidepressant use, and baseline PHQ-2, as appropriate.

Results: Overweight/obese BMI, comorbidity number, fatigue, and disability were associated with positive depression-screen, while married/partnered state, being employed, higher perceived socioeconomic status, and greater education were inversely associated with depression-screen. After adjustment, only marital status, socioeconomic status, antidepressant medication use, and fatigue were associated with risk of newly positive depression-screen. MS type, relapse number and immunomodulatory medication use were not associated with depression-screen after controlling for disability and fatigue.

Conclusion: In a large prospective cohort study of depression in people with MS, we substantiated several potential determinants of a positive depression-screen and depression trajectory, particularly fatigue. Given that fatigue is the most common and most significant clinical symptom for people with MS, efforts to reduce fatigue may have follow-on benefits for reducing depression.

Item Details

Item Type:Refereed Article
Keywords:clinical, demographic, depression, epidemiology, multiple sclerosis
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Simpson Jr, S (Dr Steve Simpson JR)
ID Code:132994
Year Published:2019
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-05-30
Last Modified:2020-08-14
Downloads:16 View Download Statistics

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