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Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS

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posted on 2023-05-20, 04:00 authored by Steve Simpson JRSteve Simpson JR, Taylor, KL, Jelinek, GA, De Livera, AM, Brown, CR, O'Kearney, E, Neate, SL, Bevens, W, Weiland, TJ
Background: Depression is highly prevalent among people with MS, and determinants thereof would be useful.

Objectives: We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS.

Methods: Positive depression-screen assessed by Patient Health Questionnaire (PHQ)-2 and PHQ-9. Associations of demographic and clinical factors with depression-screen and change thereof assessed using multivariable regression models, adjusted for age, sex, disability, fatigue, antidepressant use, and baseline PHQ-2, as appropriate.

Results: Overweight/obese BMI, comorbidity number, fatigue, and disability were associated with positive depression-screen, while married/partnered state, being employed, higher perceived socioeconomic status, and greater education were inversely associated with depression-screen. After adjustment, only marital status, socioeconomic status, antidepressant medication use, and fatigue were associated with risk of newly positive depression-screen. MS type, relapse number and immunomodulatory medication use were not associated with depression-screen after controlling for disability and fatigue.

Conclusion: In a large prospective cohort study of depression in people with MS, we substantiated several potential determinants of a positive depression-screen and depression trajectory, particularly fatigue. Given that fatigue is the most common and most significant clinical symptom for people with MS, efforts to reduce fatigue may have follow-on benefits for reducing depression.

History

Publication title

Multiple Sclerosis and Related Disorders

Volume

30

Pagination

165-175

ISSN

2211-0348

Department/School

Menzies Institute for Medical Research

Publisher

Elsevier BV

Place of publication

Netherlands

Rights statement

Copyright 2019 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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