Simpson Jr, S and Taylor, KL and Jelinek, GA and De Livera, AM and Brown, CR and O'Kearney, E and Neate, SL and Bevens, W and Weiland, TJ, Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS, Multiple Sclerosis and Related Disorders, 30 pp. 165-175. ISSN 2211-0348 (2019) [Refereed Article]
Copyright 2019 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Objectives: We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS.
Methods: Positive depression-screen assessed by Patient Health Questionnaire (PHQ)-2 and PHQ-9. Associations of demographic and clinical factors with depression-screen and change thereof assessed using multivariable regression models, adjusted for age, sex, disability, fatigue, antidepressant use, and baseline PHQ-2, as appropriate.
Results: Overweight/obese BMI, comorbidity number, fatigue, and disability were associated with positive depression-screen, while married/partnered state, being employed, higher perceived socioeconomic status, and greater education were inversely associated with depression-screen. After adjustment, only marital status, socioeconomic status, antidepressant medication use, and fatigue were associated with risk of newly positive depression-screen. MS type, relapse number and immunomodulatory medication use were not associated with depression-screen after controlling for disability and fatigue.
Conclusion: In a large prospective cohort study of depression in people with MS, we substantiated several potential determinants of a positive depression-screen and depression trajectory, particularly fatigue. Given that fatigue is the most common and most significant clinical symptom for people with MS, efforts to reduce fatigue may have follow-on benefits for reducing depression.
|Item Type:||Refereed Article|
|Keywords:||clinical, demographic, depression, epidemiology, multiple sclerosis|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Central nervous system|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Simpson Jr, S (Dr Steve Simpson JR)|
|Web of Science® Times Cited:||4|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||11 View Download Statistics|
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