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Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort

Citation

Polkinghorne, KR and Wolfe, R and Jachno, KM and Wetmore, JB and Woods, RL and McNeil, JJ and Nelson, MR and Reid, CM and Murray, AM, on behalf of the ASPREE Investigator Group, Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort, Nephrology, (January) pp. 1-9. ISSN 1320-5358 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Asian Pacific Society of Nephrology

DOI: doi:10.1111/nep.13565

Abstract

Aim: The prevalence of chronic kidney disease (CKD) in the elderly is controversial because age-related decline in kidney function may not truly reflect underlying kidney disease. We estimate the baseline prevalence and predictors of CKD using the CKD Epidemiology Collaboration (CKD-EPIeGFR ) and Berlin Initiative Study 1 (BIS1eGFR ) eGFR equations in the ASPirin in Reducing Events in the Elderly (ASPREE) trial cohort of healthy older participants.

Methods: GFR was estimated using CKD-EPI and BIS1 equations. CKD was defined as eGFR <60 mL/min/1.73 m2 or ≥ 60 mL/min/1.73 m2 with urine albumin creatinine ratio (UACR) ≥ 3 mg/mmol. Logistic regression was used to identify predictors of CKD prevalence defined by each eGFR equation.

Results: Data for analysis were complete for 17,762 participants. Mean age was 75.1 years (SD 5); 56.4% were female, 76.4% had hypertension, 9% had diabetes mellitus. Mean CKD-EPIeGFR was 73.0 (SD 14.2), compared with mean BIS1eGFR of 62.7 (11.4). Median UACR was 0.8 (IQR 0.5, 1.5) mg/mmol. Prevalence of CKD by CKD-EPIeGFR was 27% (predominantly due to normoalbuminuric stage 3a CKD), substantially lower than 47.1% by BIS1eGFR; the difference was predominantly driven by reclassification of individuals from G1 and G2 CKD to stage G3a without albuminuria. Increased prevalence of CKD by either equation was related to older age, hypertension, diabetes, or higher body mass index.

Conclusions: Prevalence of CKD with CKD-EPIeGFR was 27%, and doubled using the elderly specific BIS1eGFR, with most participants reclassified from stage 2 to stage 3a. Increased prevalence of CKD was related older age, hypertension, diabetes, or increased body mass index.

Item Details

Item Type:Refereed Article
Keywords:albuminuria, chronic kidney disease, elderly, estimated glomerular filtration rate, prevalence
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Nephrology and Urology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Urogenital System and Disorders
UTAS Author:Nelson, MR (Professor Mark Nelson)
ID Code:132980
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-05-29
Last Modified:2019-06-06
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