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Metabolic syndrome and trajectory of knee pain in older adults


Pan, F and Tian, J and Cicuttini, F and Jones, G, Metabolic syndrome and trajectory of knee pain in older adults, Osteoarthritis and Cartilage, 28, (1) pp. 45-52. ISSN 1063-4584 (2020) [Refereed Article]

Copyright Statement

2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved

DOI: doi:10.1016/j.joca.2019.05.030


Objectives: To examine the association of metabolic syndrome (MetS) and its components with knee pain severity trajectories.

Methods: Data from a population-based cohort study were utilised. Baseline blood pressure, glucose, triglycerides and high-density lipoprotein (HDL) cholesterol were measured. MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria. Radiographic knee osteoarthritis (ROA) was assessed by X-ray. Pain severity was measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain questionnaire at each time-point. Group-based trajectory modelling was used to identify pain trajectories and multi-nominal logistic regression was used for analysis. Mediation analysis was performed to assess whether body mass index (BMI)/central obesity mediated the association between MetS, its components and pain trajectories.

Results: Among 985 participants (Mean SD age: 62.9 7.4, 50% female), 32% had MetS and 60% had ROA. Three pain trajectories were identified: 'Minimal pain' (52%), 'Mild pain' (33%) and 'Moderate pain' (15%). After adjustment for potential confounders, central obesity increased risk of belonging to both 'Mild pain' and 'Moderate pain' trajectories as compared to the 'Minimal pain' trajectory group, but MetS [relative risk ratio (RRR): 2.26, 95%CI 1.50-3.39], hypertriglyceridemia (RRR: 1.75, 95%CI 1.16-2.62) and low HDL (RRR: 1.67, 95%CI 1.10-2.52) were only associated with 'Moderate pain' trajectory. BMI/central obesity explained 37-70% of these associations. Results were similar in those with ROA.

Conclusion: MetS and its components are predominantly associated with worse pain trajectories through central obesity, suggesting that the development and maintenance of worse pain trajectories may be caused by MetS.

Item Details

Item Type:Refereed Article
Keywords:metabolic syndrome, pain, trajectory, knee osteoarthritis
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Pan, F (Dr Feng Pan)
UTAS Author:Tian, J (Dr Jing Tian)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:132842
Year Published:2020 (online first 2019)
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-05-22
Last Modified:2021-01-06

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