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Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice

Citation

Collins, JM and King, AE and Woodhouse, A and Kirkcaldie, MTK and Vickers, JC, Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice, Journal of Neurotrauma, 36, (11) pp. 1876-1889. ISSN 0897-7151 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Mary Ann Liebert, Inc.

DOI: doi:10.1089/neu.2018.5982

Abstract

Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to ageing and the onset of AD pathology is not known. In this study, we have examined the effect of TBI on subsequent beta-amyloid (Aβ) deposition in APP/PS1 (APPSWE/PSEN1dE9) transgenic mice either before (3 months of age) or after the onset (6 months of age) of plaque pathology. Lateral fluid percussion (LFPI), a model of diffuse brain injury, was induced in APP/PS1 and C57Bl/6 wild-type littermates (WT). LFPI caused a significant increase in both total (p<0.001) and fibrillar (p<0.001) Aβ plaque load in the cortex of 3-month-old APP/PS1 mice compared to sham treated mice at 30 days post-injury. However, in the cortex of 6-month-old mice at 30 days post-injury, LFPI caused a significant decrease in total (p<0.01), but not fibrillar (p>0.05), Aβ plaque load compared to sham treated mice. No Aβ plaques were present in any WT mice across these conditions. GFAP-immunolabelling of astrocytes and Iba-1-immunolabelling of microglial/macrophages was not significantly different (p<0.05) in injured animals compared to sham mice, or APP/PS1 mice compared to WT mice. The current data indicates that TBI may have differential effects on Aβ plaque deposition depending on age and the stage of amyloidosis at the time of injury.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer's disease, beta-amyloid, brain Injury, APP/PS1dementia, traumatic brain Injury
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
UTAS Author:Collins, JM (Dr Jessica Collins)
UTAS Author:King, AE (Associate Professor Anna King)
UTAS Author:Woodhouse, A (Dr Adele Woodhouse)
UTAS Author:Kirkcaldie, MTK (Dr Matthew Kirkcaldie)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:132742
Year Published:2019
Web of Science® Times Cited:2
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2019-05-19
Last Modified:2019-07-05
Downloads:0

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