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How lifestyle factors and their associated pathogenetic mechanisms impact psoriasis


Madden, SK and Flanagan, KL and Jones, G, How lifestyle factors and their associated pathogenetic mechanisms impact psoriasis, Clinical Nutrition ISSN 0261-5614 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Elsevier Ltd. and European Society for Clinical Nutrition and Metabolism

DOI: doi:10.1016/j.clnu.2019.05.006


Backgrounds and aims: Psoriasis is a skin disorder affecting approximately 2-3% of the global population. While research has revealed a strong genetic component, there are few studies exploring the extent to which lifestyle factors influence psoriasis pathogenesis. The aim of this review was to describe the role of lifestyle factors as both a potential cause and treatment for psoriasis. The review also examines the underlying mechanisms through which these lifestyle factors may operate.

Methods: This narrative review aims to incorporate current knowledge relating to both lifestyle and pathogenetic factors that contribute to and alleviate psoriasis presentation. Studies reporting the effect of an inflammatory diet and potential dietary benefits are reported, as well as insights into the effects of stress, smoking and alcohol, insulin resistance and exercise.

Results: Poor nutrition and low Omega 3 fatty acid intake, likely combined with fat malabsorption caused by gut dysbiosis and systemic inflammation, are associated with psoriasis. The data strongly suggest that improvements to disease severity can be made through dietary and lifestyle interventions and increased physical activity. Less conclusive, although worthy of mention, is the beneficial effect of bile acid supplementation.

Conclusions: Lifestyle interventions are a promising treatment for psoriasis and its associated co-morbidities. However, gaps and inadequacies exist within the literature, e.g. methodology, absence of a unified scoring system, lack of controlled clinical data and lack of studies without simultaneous usage of biologics or alternative therapies. Future directions should focus on high quality cohort studies and clinical trials.

Item Details

Item Type:Refereed Article
Keywords:Psoriasis, stress, microbiota, nutrition, inflammation, lifestyle
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Dermatology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Madden, SK (Ms Seonad Madden)
UTAS Author:Flanagan, KL (Dr Katie Flanagan)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:132717
Year Published:2019
Web of Science® Times Cited:13
Deposited By:Health Sciences
Deposited On:2019-05-17
Last Modified:2022-08-25

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