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Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis

Citation

Thomas, NE and Kricker, A and From, L and Busam, K and Millikan, RC and Ritchey, ME and Armstrong, BK and Lee-Taylor, J and Marrett, LD and Anton-Culver, H and Zanetti, R and Rosso, S and Gallagher, RP and Dwyer, T and Goumas, C and Kanetsky, PA and Begg, CB and Orlow, I and Wilcox, H and Paine, S and Berwick, M and Stephens, N and The Genes, Environment, and Melanoma Study Group, Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis, Cancer Epidemiology, Biomarkers & Prevention, 19, (11) pp. 2932-2941. ISSN 1055-9965 (2010) [Refereed Article]

Copyright Statement

Copyright 2010 American Association for Cancer Research

DOI: doi:10.1158/1055-9965.EPI-10-0686

Abstract

Background: Solar elastosis adjacent to melanomas in histologic sections is regarded as an indicator of sun exposure, although the associations of UV exposure and phenotype with solar elastosis are yet to be fully explored.

Methods: The study included 2,589 incident primary melanoma patients with assessment of histologic solar elastosis in the population-based Genes, Environment, and Melanoma study. Ambient erythemal UV (UVE) at places of residence and sun exposure hours, including body site–specific exposure, were collected. We examined the association of cumulative site-specific and non–site-specific sun exposure hours and ambient UVE with solar elastosis in multivariable models adjusted for age, sex, center, pigmentary characteristics, nevi, and, where relevant, body site.

Results: Solar elastosis was associated most strongly with site-specific UVE [odds ratio (OR) for top exposure quartile, 5.20; 95% confidence interval (95% CI), 3.40-7.96; P for trend <0.001] and also with site-specific sun exposure (OR for top quartile, 5.12; 95% CI, 3.35-7.83; P for trend <0.001). Older age (OR at >70 years, 7.69; 95% CI, 5.14-11.52; P for trend < 0.001) and having more than 10 back nevi (OR, 0.77; 95% CI, 0.61-0.97; P = 0.03) were independently associated with solar elastosis.

Conclusion: Solar elastosis had a strong association with higher site-specific UVE dose, older age, and fewer nevi.

Impact: Solar elastosis could be a useful biomarker of lifetime site-specific UV. Future research is needed to explore whether age represents more than simple accumulation of sun exposure and to determine why people with more nevi may be less prone to solar elastosis.

Item Details

Item Type:Refereed Article
Keywords:melanoma, cumulative sun exposure, phenotypic characteristics
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Disease Distribution and Transmission (incl. Surveillance and Response)
UTAS Author:Stephens, N (Dr Nicola Stephens)
ID Code:132657
Year Published:2010
Web of Science® Times Cited:27
Deposited By:Medicine
Deposited On:2019-05-16
Last Modified:2019-08-08
Downloads:0

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