132602 - The influence of genetic factors and cognitive reserve on structural and functional resting-state brain networks in aging and Alzheimer's disease.pdf (1.32 MB)
The influence of genetic factors and cognitive reserve on structural and functional resting-state brain networks in aging and Alzheimer’s disease
journal contribution
posted on 2023-05-20, 03:39 authored by Manuela PietzuchManuela Pietzuch, Anna KingAnna King, Ward, DD, James VickersJames VickersMagnetic resonance imaging (MRI) offers significant insight into the complex organization of neural networks within the human brain. Using resting-state functional MRI data, topological maps can be created to visualize changes in brain activity, as well as to represent and assess the structural and functional connections between different brain regions. Crucially, Alzheimer’s disease (AD) is associated with progressive loss in this connectivity, which is particularly evident within the default mode network. In this paper, we review the recent literature on how factors that are associated with risk of dementia may influence the organization of the brain network structures. In particular, we focus on cognitive reserve and the common genetic polymorphisms of APOE and BDNF Val66Met.
History
Publication title
Frontiers in Aging NeuroscienceVolume
11Article number
30Number
30Pagination
1-14ISSN
1663-4365Department/School
Wicking Dementia Research Education CentrePublisher
Frontiers Research FoundationPlace of publication
SwitzerlandRights statement
Copyright 2019 Pietzuch, King, Ward and Vickers. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/Repository Status
- Open