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The influence of genetic factors and cognitive reserve on structural and functional resting-state brain networks in aging and Alzheimer’s disease

Citation

Pietzuch, M and King, AE and Ward, DD and Vickers, JC, The influence of genetic factors and cognitive reserve on structural and functional resting-state brain networks in aging and Alzheimer's disease, Frontiers in Aging Neuroscience, 11 pp. 1-14. ISSN 1663-4365 (2019) [Refereed Article]


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Copyright Statement

Copyright 2019 Pietzuch, King, Ward and Vickers. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fnagi.2019.00030

Abstract

Magnetic resonance imaging (MRI) offers significant insight into the complex organization of neural networks within the human brain. Using resting-state functional MRI data, topological maps can be created to visualize changes in brain activity, as well as to represent and assess the structural and functional connections between different brain regions. Crucially, Alzheimer’s disease (AD) is associated with progressive loss in this connectivity, which is particularly evident within the default mode network. In this paper, we review the recent literature on how factors that are associated with risk of dementia may influence the organization of the brain network structures. In particular, we focus on cognitive reserve and the common genetic polymorphisms of APOE and BDNF Val66Met.

Item Details

Item Type:Refereed Article
Keywords:fMRI, Alzheimer's disease, default mode network, cognitive reserve, BDNF, APOE, dementia, genetics, ageing
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
UTAS Author:Pietzuch, M (Miss Manuela Pietzuch)
UTAS Author:King, AE (Professor Anna King)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:132602
Year Published:2019
Web of Science® Times Cited:1
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2019-05-14
Last Modified:2019-06-14
Downloads:2 View Download Statistics

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