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132602 - The influence of genetic factors and cognitive reserve on structural and functional resting-state brain networks in aging and Alzheimer's disease.pdf (1.32 MB)

The influence of genetic factors and cognitive reserve on structural and functional resting-state brain networks in aging and Alzheimer’s disease

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posted on 2023-05-20, 03:39 authored by Manuela PietzuchManuela Pietzuch, Anna KingAnna King, Ward, DD, James VickersJames Vickers
Magnetic resonance imaging (MRI) offers significant insight into the complex organization of neural networks within the human brain. Using resting-state functional MRI data, topological maps can be created to visualize changes in brain activity, as well as to represent and assess the structural and functional connections between different brain regions. Crucially, Alzheimer’s disease (AD) is associated with progressive loss in this connectivity, which is particularly evident within the default mode network. In this paper, we review the recent literature on how factors that are associated with risk of dementia may influence the organization of the brain network structures. In particular, we focus on cognitive reserve and the common genetic polymorphisms of APOE and BDNF Val66Met.

History

Publication title

Frontiers in Aging Neuroscience

Volume

11

Article number

30

Number

30

Pagination

1-14

ISSN

1663-4365

Department/School

Wicking Dementia Research Education Centre

Publisher

Frontiers Research Foundation

Place of publication

Switzerland

Rights statement

Copyright 2019 Pietzuch, King, Ward and Vickers. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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