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The metabolomic signatures of alcohol consumption in young adults
Citation
Du, D and Bruno, R and Blizzard, L and Venn, A and Dwyer, T and Smith, KJ and Magnussen, CG and Gall, S, The metabolomic signatures of alcohol consumption in young adults, European Journal of Preventive Cardiology, (March) pp. 1-10. ISSN 2047-4873 (2019) [Refereed Article]
Copyright Statement
Copyright 2019 The European Society of Cardiology
DOI: doi:10.1177/2047487319834767
Abstract
Background: Metabolomic analysis may help us to understand the association between alcohol consumption and cardio-metabolic health. We aimed to: (i) replicate a previous study of alcohol consumption and metabolic profiles, (ii) examine associations between types of alcoholic beverages and metabolites and (iii) include potential confounders not examined in previous studies.
Methods: Cross-sectional data of 1785 participants (age 26-36 years, 52% women) from the 2004-2006 Childhood Determinants of Adult Health study were used. Consumption of beer, wine and spirits was assessed by questionnaires. Metabolites were measured by a high-throughput nuclear magnetic resonance platform and multivariable linear regression examined their association with alcohol consumption (combined total and types) adjusted for covariates including socio-demographics, health behaviours and mental health.
Results: Alcohol consumption was associated with 23 out of 37 lipids, 12 out of 16 fatty acids and six out of 20 low-molecular-weight metabolites independent of confounders with similar associations for combined total alcohol consumption and different types of alcohol. Many metabolites (lipoprotein lipids in high-density lipoprotein (HDL) subclasses, HDL cholesterol, apolipoprotein A-1, phosphotriglycerides, total fatty acids, monounsaturated fatty acids, omega-3 fatty acids) had positive linear associations with alcohol consumption but some showed negative linear (low-density lipoprotein particle size, omega-6 fatty acids ratio to total fatty acids, citrate) or U-shaped (lipoprotein lipids in very-low-density lipoprotein (VLDL) subclasses, VLDL triglycerides) associations.
Conclusions: Our results were similar to those of the only previous study. Associations with metabolites were similar for total and types of alcohol. Alcohol consumption in young adults is related to a diverse range of metabolomic signatures associated with benefits and harms to health.
Item Details
Item Type: | Refereed Article |
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Keywords: | alcohol, epidemiology, risk factors, metabolomics, fatty acids, metabolic profiling, cardiometabolic health |
Research Division: | Psychology |
Research Group: | Other psychology |
Research Field: | Other psychology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Public health (excl. specific population health) not elsewhere classified |
UTAS Author: | Du, D (Mr Duc Du) |
UTAS Author: | Bruno, R (Associate Professor Raimondo Bruno) |
UTAS Author: | Blizzard, L (Professor Leigh Blizzard) |
UTAS Author: | Venn, A (Professor Alison Venn) |
UTAS Author: | Dwyer, T (Professor Terry Dwyer) |
UTAS Author: | Smith, KJ (Dr Kylie Smith) |
UTAS Author: | Magnussen, CG (Associate Professor Costan Magnussen) |
UTAS Author: | Gall, S (Associate Professor Seana Gall) |
ID Code: | 132587 |
Year Published: | 2019 |
Funding Support: | National Health and Medical Research Council (211316) |
Web of Science® Times Cited: | 1 |
Deposited By: | Psychology |
Deposited On: | 2019-05-14 |
Last Modified: | 2020-02-25 |
Downloads: | 0 |
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