Du, D and Bruno, R and Blizzard, L and Venn, A and Dwyer, T and Smith, KJ and Magnussen, CG and Gall, S, The metabolomic signatures of alcohol consumption in young adults, European Journal of Preventive Cardiology, (March) pp. 1-10. ISSN 2047-4873 (2019) [Refereed Article]
Copyright 2019 The European Society of Cardiology
Background: Metabolomic analysis may help us to understand the association between alcohol consumption and cardio-metabolic health. We aimed to: (i) replicate a previous study of alcohol consumption and metabolic profiles, (ii) examine associations between types of alcoholic beverages and metabolites and (iii) include potential confounders not examined in previous studies.
Methods: Cross-sectional data of 1785 participants (age 26-36 years, 52% women) from the 2004-2006 Childhood Determinants of Adult Health study were used. Consumption of beer, wine and spirits was assessed by questionnaires. Metabolites were measured by a high-throughput nuclear magnetic resonance platform and multivariable linear regression examined their association with alcohol consumption (combined total and types) adjusted for covariates including socio-demographics, health behaviours and mental health.
Results: Alcohol consumption was associated with 23 out of 37 lipids, 12 out of 16 fatty acids and six out of 20 low-molecular-weight metabolites independent of confounders with similar associations for combined total alcohol consumption and different types of alcohol. Many metabolites (lipoprotein lipids in high-density lipoprotein (HDL) subclasses, HDL cholesterol, apolipoprotein A-1, phosphotriglycerides, total fatty acids, monounsaturated fatty acids, omega-3 fatty acids) had positive linear associations with alcohol consumption but some showed negative linear (low-density lipoprotein particle size, omega-6 fatty acids ratio to total fatty acids, citrate) or U-shaped (lipoprotein lipids in very-low-density lipoprotein (VLDL) subclasses, VLDL triglycerides) associations.
Conclusions: Our results were similar to those of the only previous study. Associations with metabolites were similar for total and types of alcohol. Alcohol consumption in young adults is related to a diverse range of metabolomic signatures associated with benefits and harms to health.
|Item Type:||Refereed Article|
|Keywords:||alcohol, epidemiology, risk factors, metabolomics, fatty acids, metabolic profiling, cardiometabolic health|
|Research Division:||Psychology and Cognitive Sciences|
|Research Group:||Other Psychology and Cognitive Sciences|
|Research Field:||Psychology and Cognitive Sciences not elsewhere classified|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Objective Field:||Substance Abuse|
|UTAS Author:||Du, D (Mr Duc Du)|
|UTAS Author:||Bruno, R (Associate Professor Raimondo Bruno)|
|UTAS Author:||Blizzard, L (Professor Leigh Blizzard)|
|UTAS Author:||Venn, A (Professor Alison Venn)|
|UTAS Author:||Dwyer, T (Professor Terry Dwyer)|
|UTAS Author:||Smith, KJ (Dr Kylie Smith)|
|UTAS Author:||Magnussen, CG (Dr Costan Magnussen)|
|UTAS Author:||Gall, S (Associate Professor Seana Gall)|
|Funding Support:||National Health and Medical Research Council (211316)|
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