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The metabolomic signatures of alcohol consumption in young adults

Citation

Du, DH and Bruno, R and Blizzard, L and Venn, A and Dwyer, T and Smith, KJ and Magnussen, CG and Gall, S, The metabolomic signatures of alcohol consumption in young adults, European Journal of Preventive Cardiology, (March) pp. 1-10. ISSN 2047-4873 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 The European Society of Cardiology

DOI: doi:10.1177/2047487319834767

Abstract

Background: Metabolomic analysis may help us to understand the association between alcohol consumption and cardio-metabolic health. We aimed to: (i) replicate a previous study of alcohol consumption and metabolic profiles, (ii) examine associations between types of alcoholic beverages and metabolites and (iii) include potential confounders not examined in previous studies.

Methods: Cross-sectional data of 1785 participants (age 26-36 years, 52% women) from the 2004-2006 Childhood Determinants of Adult Health study were used. Consumption of beer, wine and spirits was assessed by questionnaires. Metabolites were measured by a high-throughput nuclear magnetic resonance platform and multivariable linear regression examined their association with alcohol consumption (combined total and types) adjusted for covariates including socio-demographics, health behaviours and mental health.

Results: Alcohol consumption was associated with 23 out of 37 lipids, 12 out of 16 fatty acids and six out of 20 low-molecular-weight metabolites independent of confounders with similar associations for combined total alcohol consumption and different types of alcohol. Many metabolites (lipoprotein lipids in high-density lipoprotein (HDL) subclasses, HDL cholesterol, apolipoprotein A-1, phosphotriglycerides, total fatty acids, monounsaturated fatty acids, omega-3 fatty acids) had positive linear associations with alcohol consumption but some showed negative linear (low-density lipoprotein particle size, omega-6 fatty acids ratio to total fatty acids, citrate) or U-shaped (lipoprotein lipids in very-low-density lipoprotein (VLDL) subclasses, VLDL triglycerides) associations.

Conclusions: Our results were similar to those of the only previous study. Associations with metabolites were similar for total and types of alcohol. Alcohol consumption in young adults is related to a diverse range of metabolomic signatures associated with benefits and harms to health.

Item Details

Item Type:Refereed Article
Keywords:alcohol, epidemiology, risk factors, metabolomics, fatty acids, metabolic profiling, cardiometabolic health
Research Division:Psychology and Cognitive Sciences
Research Group:Other Psychology and Cognitive Sciences
Research Field:Psychology and Cognitive Sciences not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Substance Abuse
UTAS Author:Du, DH (Mr Duc Du)
UTAS Author:Bruno, R (Associate Professor Raimondo Bruno)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Smith, KJ (Dr Kylie Smith)
UTAS Author:Magnussen, CG (Dr Costan Magnussen)
UTAS Author:Gall, S (Associate Professor Seana Gall)
ID Code:132587
Year Published:2019
Funding Support:National Health and Medical Research Council (211316)
Deposited By:Psychology
Deposited On:2019-05-14
Last Modified:2019-06-14
Downloads:0

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