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Parathyroid-hormone-related protein in sarcoidosis


Zeimer, HJ and Greenaway, TM and Slavin, J and Hards, DK and Zhou, H and Doery, JCG and Hunter, AN and Duffield, A and Martin, TJ and Grill, V, Parathyroid-hormone-related protein in sarcoidosis, American Journal of Pathology, 152, (1) pp. 17-21. ISSN 0002-9440 (1998) [Refereed Article]


Parathyroid-hormone-related protein (PTHrP) is the main mediator of the humoral hypercalcemia of malignancy. It is also detected in many normal adult and fetal tissues. Altered calcium metabolism occurs in sarcoidosis, and two cases of sarcoidosis with hypercalcemia and elevated plasma PTHrP are described. An archival study of 20 lymph node biopsies with the pathological diagnosis of sarcoidosis was performed. Immunohistochemistry using a polyclonal antiserum to human PTHrP and in situ hybridization using a riboprobe to human PTHrP were performed on the lymph node biopsies. Immunohistochemistry for PTHrP was also performed on the biopsies from the two cases with elevated plasma levels. Immunohistochemical analysis detected PTHrP in macrophages within granulomata in 17 of the 20 (85%) biopsies. In situ hybridization detected a positive signal for messenger RNA in the granulomata of 11 of 19 (58%) biopsies. PTHrP immunoreactivity and PTHrP gene expression are present in sarcoid granulomata. PTHrP may contribute to the hypercalcemia of sarcoidosis.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Greenaway, TM (Dr Tim Greenaway)
UTAS Author:Duffield, A (Dr Anne Duffield)
ID Code:13229
Year Published:1998
Web of Science® Times Cited:51
Deposited By:Medicine
Deposited On:1998-08-01
Last Modified:2011-08-08

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