van Sloten, TT and Boutouyrie, P and Tafflet, M and Offredo, L and Thomas, F and Guibout, C and Climie, RE and Lemogne, C and Pannier, B and Laurent, S and Jouven, X and Empana, J-P, Carotid artery stiffness and incident depressive symptoms: The Paris Prospective Study III, Biological Psychiatry, 85, (6) pp. 498-505. ISSN 0006-3223 (2019) [Refereed Article]
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Copyright 2018 Society of Biological Psychiatry
Methods: This longitudinal study included 7013 participants (mean age 59.7 ± 6.3 years; 35.8% women) free of depressive symptoms at baseline. Carotid artery stiffness (high-resolution echo tracking) was determined at baseline. Presence of depressive symptoms was determined at baseline and at 4 and 6 years of follow-up, and was defined as a score ≥7 on the validated Questionnaire of Depression, Second Version, Abridged and/or new use of antidepressant medication. Logistic regression and generalized estimating equations were used.
Results: In total, 6.9% (n = 484) of the participants had incident depressive symptoms. Individuals in the lowest tertile of carotid distensibility coefficient (indicating greater carotid artery stiffness) compared with those in the highest tertile had a higher risk of incident depressive symptoms (odds ratio: 1.43; 95% confidence interval: 1.10-1.87), after adjustment for age, sex, living alone, education, lifestyle, cardiovascular risk factors, and baseline Questionnaire of Depression, Second Version, Abridged scores. Results were qualitatively similar when we used carotid Young's elastic modulus as a measure of carotid stiffness instead of carotid distensibility coefficient, and when we used generalized estimating equations instead of logistic regression.
Conclusions: Greater carotid stiffness is associated with a higher incidence of depressive symptoms. This supports the hypothesis that carotid stiffness may contribute to the development of late-life depression.
|Item Type:||Refereed Article|
|Keywords:||aging, arterial stiffness, epidemiology, late-life depression, longitudinal studies, vascular depression|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Behaviour and health|
|UTAS Author:||Climie, RE (Miss Rachel Climie)|
|Web of Science® Times Cited:||13|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||6 View Download Statistics|
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