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Carotid artery stiffness and incident depressive symptoms: The Paris Prospective Study III

Citation

van Sloten, TT and Boutouyrie, P and Tafflet, M and Offredo, L and Thomas, F and Guibout, C and Climie, RE and Lemogne, C and Pannier, B and Laurent, S and Jouven, X and Empana, J-P, Carotid artery stiffness and incident depressive symptoms: The Paris Prospective Study III, Biological Psychiatry, 85, (6) pp. 498-505. ISSN 0006-3223 (2019) [Refereed Article]


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Copyright Statement

Copyright 2018 Society of Biological Psychiatry

DOI: doi:10.1016/j.biopsych.2018.09.018

Abstract

Background: Arterial stiffness may contribute to late-life depression via cerebral microvascular damage, but evidence is scarce. No longitudinal study has evaluated the association between arterial stiffness and risk of depressive symptoms. Therefore, we investigated the association between carotid artery stiffness and incident depressive symptoms in a large community-based cohort study.

Methods: This longitudinal study included 7013 participants (mean age 59.7 6.3 years; 35.8% women) free of depressive symptoms at baseline. Carotid artery stiffness (high-resolution echo tracking) was determined at baseline. Presence of depressive symptoms was determined at baseline and at 4 and 6 years of follow-up, and was defined as a score ≥7 on the validated Questionnaire of Depression, Second Version, Abridged and/or new use of antidepressant medication. Logistic regression and generalized estimating equations were used.

Results: In total, 6.9% (n = 484) of the participants had incident depressive symptoms. Individuals in the lowest tertile of carotid distensibility coefficient (indicating greater carotid artery stiffness) compared with those in the highest tertile had a higher risk of incident depressive symptoms (odds ratio: 1.43; 95% confidence interval: 1.10-1.87), after adjustment for age, sex, living alone, education, lifestyle, cardiovascular risk factors, and baseline Questionnaire of Depression, Second Version, Abridged scores. Results were qualitatively similar when we used carotid Young's elastic modulus as a measure of carotid stiffness instead of carotid distensibility coefficient, and when we used generalized estimating equations instead of logistic regression.

Conclusions: Greater carotid stiffness is associated with a higher incidence of depressive symptoms. This supports the hypothesis that carotid stiffness may contribute to the development of late-life depression.

Item Details

Item Type:Refereed Article
Keywords:aging, arterial stiffness, epidemiology, late-life depression, longitudinal studies, vascular depression
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Behaviour and Health
UTAS Author:Climie, RE (Miss Rachel Climie)
ID Code:132282
Year Published:2019
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-05-01
Last Modified:2020-03-11
Downloads:3 View Download Statistics

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