Cervo, MM and Shivappa, N and Hebert, JR and Oddy, WH and Winzenberg, T and Balogun, S and Wu, F and Ebeling, P and Aitken, D and Jones, G and Scott, D, Longitudinal associations between dietary inflammatory index and musculoskeletal health in community-dwelling older adults, Clinical Nutrition pp. 1-8. ISSN 0261-5614 (2019) [Refereed Article]
Copyright 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
Methods: A total of 1098 [51% male; age (mean ± SD) 63.0 ± 7.5 years] non-institutionalized older adults who participated in the Tasmanian Older Adult Cohort Study (TASOAC) at baseline, 768 at 5 years, and 566 at 10 years follow-up were included in this analysis. Baseline energy-adjusted DII (E-DII) scores were calculated using a validated Food Frequency Questionnaire. Changes in bone mineral density (BMD) and appendicular lean mass (ALM) were measured over ten years using dual-energy x-ray absorptiometry. Ten-year changes in hand grip, knee extensor and whole lower-limb muscle strength and quality were assessed by dynamometers and change in falls risk score using the Physical Profile Assessment (PPA). Incident fractures at any site and non-vertebral fractures over 10 years were self-reported.
Results: The E-DII range was -3.48 to +3.23 in men and -3.80 to +2.74 in women. Higher E-DII score (indicating a more pro-inflammatory diet) was associated with lower total hip (B: -0.009; 95% CI: -0.017, 0.000) and lumbar spine BMD (B: -0.013; 95% CI: -0.024, -0.002), and higher falls risk score (B: 0.040; 95% CI: 0.002, 0.078) over 10 years in men. Women with higher E-DII scores had higher whole lower-limb muscle quality over 10 years (B: 0.109; 95% CI: 0.002, 0.215). For every unit increase in E-DII score, incident fracture rates increased by 9.0% in men (IRR: 1.090; 95% CI: 1.011, 1.175) and decreased by 12.2% in women (IRR: 0.878; 95% CI: 0.800, 0.964) in a fully adjusted model.
Conclusion: Higher E-DII scores were associated with lower bone density, higher falls risk, and increased incidence of fractures in community-dwelling older men, but decreased fracture incidence in women, over 10 years. This suggests pro-inflammatory diets may be more detrimental to musculoskeletal health in older men than in women. Additional studies are warranted to elucidate these sex differences.
|Item Type:||Refereed Article|
|Keywords:||dietary inflammatory index, chronic inflammation, fractures, bone mineral density, sarcopenia, falls risk|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Public Health (excl. Specific Population Health)|
|UTAS Author:||Oddy, WH (Professor Wendy Oddy)|
|UTAS Author:||Winzenberg, T (Professor Tania Winzenberg)|
|UTAS Author:||Balogun, S (Dr Saliu Balogun)|
|UTAS Author:||Wu, F (Dr Feitong Wu)|
|UTAS Author:||Aitken, D (Associate Professor Dawn Aitken)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Scott, D (Mr David Scott)|
|Web of Science® Times Cited:||49|
|Deposited By:||Menzies Institute for Medical Research|
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