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Longitudinal associations between dietary inflammatory index and musculoskeletal health in community-dwelling older adults

Citation

Cervo, MM and Shivappa, N and Hebert, JR and Oddy, WH and Winzenberg, T and Balogun, S and Wu, F and Ebeling, P and Aitken, D and Jones, G and Scott, D, Longitudinal associations between dietary inflammatory index and musculoskeletal health in community-dwelling older adults, Clinical Nutrition pp. 1-8. ISSN 0261-5614 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism

DOI: doi:10.1016/j.clnu.2019.02.031

Abstract

Background & Aims: Aging is characterized by progressive decline in physiologic reserves and functions as well as prolonged inflammation, increasing susceptibility to disease. Diet plays an important role in maintaining health, and reducing morbidity and mortality, especially in older populations. This study was designed to determine prospective associations between dietary inflammatory index (DII) scores and bone health, sarcopenia-related outcomes, falls risk and incident fractures in community-dwelling Australian older adults.

Methods: A total of 1098 [51% male; age (mean SD) 63.0 7.5 years] non-institutionalized older adults who participated in the Tasmanian Older Adult Cohort Study (TASOAC) at baseline, 768 at 5 years, and 566 at 10 years follow-up were included in this analysis. Baseline energy-adjusted DII (E-DII) scores were calculated using a validated Food Frequency Questionnaire. Changes in bone mineral density (BMD) and appendicular lean mass (ALM) were measured over ten years using dual-energy x-ray absorptiometry. Ten-year changes in hand grip, knee extensor and whole lower-limb muscle strength and quality were assessed by dynamometers and change in falls risk score using the Physical Profile Assessment (PPA). Incident fractures at any site and non-vertebral fractures over 10 years were self-reported.

Results: The E-DII range was -3.48 to +3.23 in men and -3.80 to +2.74 in women. Higher E-DII score (indicating a more pro-inflammatory diet) was associated with lower total hip (B: -0.009; 95% CI: -0.017, 0.000) and lumbar spine BMD (B: -0.013; 95% CI: -0.024, -0.002), and higher falls risk score (B: 0.040; 95% CI: 0.002, 0.078) over 10 years in men. Women with higher E-DII scores had higher whole lower-limb muscle quality over 10 years (B: 0.109; 95% CI: 0.002, 0.215). For every unit increase in E-DII score, incident fracture rates increased by 9.0% in men (IRR: 1.090; 95% CI: 1.011, 1.175) and decreased by 12.2% in women (IRR: 0.878; 95% CI: 0.800, 0.964) in a fully adjusted model.

Conclusion: Higher E-DII scores were associated with lower bone density, higher falls risk, and increased incidence of fractures in community-dwelling older men, but decreased fracture incidence in women, over 10 years. This suggests pro-inflammatory diets may be more detrimental to musculoskeletal health in older men than in women. Additional studies are warranted to elucidate these sex differences.

Item Details

Item Type:Refereed Article
Keywords:dietary inflammatory index, chronic inflammation, fractures, bone mineral density, sarcopenia, falls risk
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Nutrition
UTAS Author:Oddy, WH (Professor Wendy Oddy)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Balogun, S (Dr Saliu Balogun)
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Scott, D (Mr David Scott)
ID Code:132277
Year Published:2019
Web of Science® Times Cited:49
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-05-01
Last Modified:2019-08-02
Downloads:0

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