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Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain

Citation

Cullen, CL and Senesi, M and Tang, AD and Clutterbuck, MT and Auderset, L and O'Rourke, ME and Rodger, J and Young, KM, Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain, Glia pp. 1-16. ISSN 0894-1491 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Wiley Periodicals, Inc.

DOI: doi:10.1002/glia.23620

Abstract

Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre-lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI-rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI-rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI-rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis.

Item Details

Item Type:Refereed Article
Keywords:adaptive myelination, cortex, internode, myelin, oligodendrocyte survival, oligodendrogenesis, transcranial magnetic stimulation
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
UTAS Author:Cullen, CL (Dr Carlie Cullen)
UTAS Author:Senesi, M (Mr Matteo Senesi)
UTAS Author:Clutterbuck, MT (Mr Mackenzie Clutterbuck)
UTAS Author:Auderset, L (Mr Loic Auderset)
UTAS Author:O'Rourke, ME (Ms Megan O'Rourke)
UTAS Author:Young, KM (Associate Professor Kaylene Young)
ID Code:132171
Year Published:2019
Funding Support:National Health and Medical Research Council (1139041)
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-04-26
Last Modified:2019-10-14
Downloads:0

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