Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre-lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI-rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI-rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI-rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis.

Item Type:	Refereed Article
Keywords:	adaptive myelination, cortex, internode, myelin, oligodendrocyte survival, oligodendrogenesis, transcranial magnetic stimulation
Research Division:	Biomedical and Clinical Sciences
Research Group:	Neurosciences
Research Field:	Central nervous system
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Cullen, CL (Dr Carlie Cullen)
UTAS Author:	Senesi, M (Mr Matteo Senesi)
UTAS Author:	Clutterbuck, MT (Mr Mackenzie Clutterbuck)
UTAS Author:	Auderset, LF (Mr Loic Auderset)
UTAS Author:	O'Rourke, ME (Ms Megan O'Rourke)
UTAS Author:	Young, KM (Professor Kaylene Young)
ID Code:	132171
Year Published:	2019
Funding Support:	National Health and Medical Research Council (1139041)
Web of Science® Times Cited:	36
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2019-04-26
Last Modified:	2022-08-23
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