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Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood
Citation
Cuthbertson, DJ and Brown, E and Koskinen, J and Magnussen, CG and Hutri-Kahonen, N and Sabin, M and Tossavainen, P and Jokinen, E and Laitinen, T and Viikari, J and Raitakari, OT and Juonala, M, Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood, Liver International, 39, (6) pp. 1147-1154. ISSN 1478-3223 (2019) [Refereed Article]
Copyright Statement
Copyright 2018 John Wiley & Sons A/S.
Abstract
Methods: Data from 2020 participants aged 3-18 years at baseline, followed up 31 years later, were examined to assess the utility of four childhood metabolic phenotypes (Metabolic Groups I: normal body mass index, no metabolic disturbances; II: normal body mass index, one or more metabolic disturbances; III: overweight/obese, no metabolic disturbances; IV: overweight/obese, one or more metabolic disturbances) and four life-course adiposity phenotypes (Adiposity Group 1: normal child and adult body mass index; 2, high child, normal adult body mass index; 3, normal child body mass index, high adult body mass index; 4, high child and adult body mass index) in predicting adult non-alcoholic fatty liver disease.
Results: The risk for adult non-alcoholic fatty liver disease was similar across all four groups after adjustment for age, sex, lifestyle factors and adult body mass index. Risk of adult non-alcoholic fatty liver disease was not increased among individuals overweight/obese in childhood but non-obese in adulthood. In contrast, overweight or obese adults, irrespective of their youth body mass index status, had ~eight-fold to 10-fold increased risk (P < 0.001).
Conclusions: Childhood overweight/obesity, not metabolic health, is associated with increased risk for adult non-alcoholic fatty liver disease. However, the increased risk associated with childhood overweight/obesity can be largely removed by obtaining a normal body mass index by adulthood.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | metabolic health, non-alcoholic fatty liver disease, obesity, risk |
| Research Division: | Health Sciences |
| Research Group: | Epidemiology |
| Research Field: | Epidemiology not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Magnussen, CG (Associate Professor Costan Magnussen) |
| ID Code: | 132075 |
| Year Published: | 2019 |
| Web of Science® Times Cited: | 12 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2019-04-17 |
| Last Modified: | 2020-04-06 |
| Downloads: | 0 |
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