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Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood
Cuthbertson, DJ and Brown, E and Koskinen, J and Magnussen, CG and Hutri-Kahonen, N and Sabin, M and Tossavainen, P and Jokinen, E and Laitinen, T and Viikari, J and Raitakari, OT and Juonala, M, Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood, Liver International, 39, (6) pp. 1147-1154. ISSN 1478-3223 (2019) [Refereed Article]
Copyright 2018 John Wiley & Sons A/S.
Methods: Data from 2020 participants aged 3-18 years at baseline, followed up 31 years later, were examined to assess the utility of four childhood metabolic phenotypes (Metabolic Groups I: normal body mass index, no metabolic disturbances; II: normal body mass index, one or more metabolic disturbances; III: overweight/obese, no metabolic disturbances; IV: overweight/obese, one or more metabolic disturbances) and four life-course adiposity phenotypes (Adiposity Group 1: normal child and adult body mass index; 2, high child, normal adult body mass index; 3, normal child body mass index, high adult body mass index; 4, high child and adult body mass index) in predicting adult non-alcoholic fatty liver disease.
Results: The risk for adult non-alcoholic fatty liver disease was similar across all four groups after adjustment for age, sex, lifestyle factors and adult body mass index. Risk of adult non-alcoholic fatty liver disease was not increased among individuals overweight/obese in childhood but non-obese in adulthood. In contrast, overweight or obese adults, irrespective of their youth body mass index status, had ~eight-fold to 10-fold increased risk (P < 0.001).
Conclusions: Childhood overweight/obesity, not metabolic health, is associated with increased risk for adult non-alcoholic fatty liver disease. However, the increased risk associated with childhood overweight/obesity can be largely removed by obtaining a normal body mass index by adulthood.
|Item Type:||Refereed Article|
|Keywords:||metabolic health, non-alcoholic fatty liver disease, obesity, risk|
|Research Division:||Health Sciences|
|Research Field:||Epidemiology not elsewhere classified|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Magnussen, CG (Associate Professor Costan Magnussen)|
|Web of Science® Times Cited:||12|
|Deposited By:||Menzies Institute for Medical Research|
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