eCite Digital Repository

A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila


Clyne, PJ and Warr, CG and Freeman, MR and Lessing, D and Kim, J and Carlson, JR, A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila, Neuron, 22, (2) pp. 327-338. ISSN 0896-6273 (1999) [Refereed Article]

DOI: doi:10.1016/S0896-6273(00)81093-4


Although insects have proven to be valuable models for exploring the function, organization, and development of the olfactory system, the receptor molecules that bind odors have not been identified in any insect. We have developed a novel search algorithm, used it to search the Drosophila genomic sequence database, and identified a large multigene family encoding seven transmembrane domain proteins that are expressed in olfactory organs. We show that expression is restricted to subsets of olfactory receptor neurons (ORNs) for a number of these genes. Different members of the family initiate expression at different times during antennal development. Some of the genes are not expressed in a mutant of the Acj6 POU-domain transcription factor, a mutant in which a subset of ORNs show abnormal odorant specificities.

Item Details

Item Type:Refereed Article
Keywords:amino acid; DNA; guanine nucleotide binding protein; protein; receptor; RNA; algorithm; amino acid sequence; article; DNA sequence; Drosophila; gene; gene expression; in situ hybridization; nonhuman; olfactory system; open reading frame
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Neurogenetics
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Warr, CG (Professor Coral Warr)
ID Code:131995
Year Published:1999
Web of Science® Times Cited:829
Deposited By:Office of the School of Medicine
Deposited On:2019-04-16
Last Modified:2019-04-16

Repository Staff Only: item control page