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Candidate taste receptors in Drosophila


Clyne, PJ and Warr, CG and Carlson, JR, Candidate taste receptors in Drosophila, Science, 287, (5459) pp. 1830-1834. ISSN 0036-8075 (2000) [Refereed Article]

DOI: doi:10.1126/science.287.5459.1830


Little is known about the molecular mechanisms of taste perception in animals, particularly the initial events of taste signaling. A large and diverse family of seven transmembrane domain proteins was identified from the Drosophila genome database with a computer algorithm that identifies proteins on the basis of structure. Eighteen of 19 genes examined were expressed in the Drosophila labellum, a gustatory organ of the proboscis. Expression was not detected in a variety of other tissues. The genes were not expressed in the labellum of a Drosophila mutant, pox-neuro 70, in which taste neurons are eliminated. Tissue specificity of expression of these genes, along with their structural similarity, supports the possibility that the family encodes a large and divergent family of taste receptors.

Item Details

Item Type:Refereed Article
Keywords:membrane protein; animal tissue; article; controlled study; Drosophila; gene expression; genome; gustatory system; nonhuman; priority journal; protein analysis; protein domain; protein family; signal transduction; taste bud; tissue specificity
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Neurogenetics
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Warr, CG (Professor Coral Warr)
ID Code:131987
Year Published:2000
Web of Science® Times Cited:420
Deposited By:Office of the School of Medicine
Deposited On:2019-04-16
Last Modified:2019-04-16

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