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Functional and molecular evolution of olfactory neurons and receptors for aliphatic esters across the Drosophila genus

Citation

de Bruyne, M and Smart, R and Zammit, E and Warr, CG, Functional and molecular evolution of olfactory neurons and receptors for aliphatic esters across the Drosophila genus, Journal of Comparative Physiology A, 196, (2) pp. 97-109. ISSN 0340-7594 (2010) [Refereed Article]

DOI: doi:10.1007/s00359-009-0496-6

Abstract

Insect olfactory receptor (Or) genes are large, rapidly evolving gene families of considerable interest for evolutionary studies. They determine the responses of sensory neurons which mediate critical behaviours and ecological adaptations. We investigated the evolution across the genus Drosophila of a subfamily of Or genes largely responsible for the perception of ecologically relevant aliphatic esters; products of yeast fermentation and fruits. Odour responses were recorded from eight classes of olfactory receptor neurons known to express this Or subfamily in D. melanogaster and from homologous sensilla in seven other species. Despite the fact that these species have diverged over an estimated 40 million years, we find that odour specificity is largely maintained in seven of the eight species. In contrast, we observe extensive changes in most neurons of the outgroup species D. virilis, and in two neurons across the entire genus. Some neurons show small shifts in specificity, whilst some dramatic changes correlate with gene duplication or loss. An olfactory receptor neuron response similarity tree did not match an Or sequence similarity tree, but by aligning Or proteins of likely functional equivalence we identify residues that may be relevant for odour specificity. This will inform future structure-function studies of Drosophila Ors.

Item Details

Item Type:Refereed Article
Keywords:Evolution; Odour response profile; Olfaction; Olfactory receptors; Receptor neurons; acetic acid derivative; Drosophila protein; action potential; amino acid sequence; animal; article; chemical structure; classification; cytology; Drosophila; odor
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Neurogenetics
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Warr, CG (Professor Coral Warr)
ID Code:131891
Year Published:2010
Web of Science® Times Cited:31
Deposited By:Office of the School of Medicine
Deposited On:2019-04-11
Last Modified:2019-04-11
Downloads:0

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