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The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference
journal contribution
posted on 2023-05-20, 02:38 authored by Rances, E, Johnson, TK, Popovici, J, Iturbe-Ormaetxe, I, Zakir, T, Coral WarrCoral Warr, O'Neill, SLWolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti. Using the Drosophila model and mutations in the Toll and Imd pathways, we showed that neither pathway is required for expression of the dengue virusblocking phenotype in the Drosophila host. This provides additional evidence that the mechanistic basis of Wolbachia-mediated dengue virus blocking in insects is more complex than simple priming of the host insect innate immune system.
History
Publication title
Journal of VirologyVolume
87Issue
21Pagination
11945-11949ISSN
0022-538XDepartment/School
Tasmanian School of MedicinePublisher
Amer Soc MicrobiologyPlace of publication
1752 N St Nw, Washington, USA, Dc, 20036-2904Repository Status
- Restricted