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The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference


Rances, E and Johnson, TK and Popovici, J and Iturbe-Ormaetxe, I and Zakir, T and Warr, CG and O'Neill, SL, The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference, Journal of Virology, 87, (21) pp. 11945-11949. ISSN 0022-538X (2013) [Refereed Article]

DOI: doi:10.1128/JVI.01522-13


Wolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti. Using the Drosophila model and mutations in the Toll and Imd pathways, we showed that neither pathway is required for expression of the dengue virusblocking phenotype in the Drosophila host. This provides additional evidence that the mechanistic basis of Wolbachia-mediated dengue virus blocking in insects is more complex than simple priming of the host insect innate immune system.

Item Details

Item Type:Refereed Article
Keywords:protein Imd; protein Toll; unclassified drug; animal experiment; animal tissue; article; Dengue virus; Drosophila melanogaster; female; gene expression; Imd gene; innate immunity; male; mutational analysis; nonhuman; phenotype; priority journal
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetic immunology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Warr, CG (Professor Coral Warr)
ID Code:131855
Year Published:2013
Web of Science® Times Cited:54
Deposited By:Office of the School of Medicine
Deposited On:2019-04-09
Last Modified:2019-04-09

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