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Stability of milrinone in continuous ambulatory delivery devices

Citation

Al Madfai, F and Zaidi, STR and Ming, LC and Wanandy, T and Patel, RP, Stability of milrinone in continuous ambulatory delivery devices, American Journal of Health-System Pharmacy, 75, (9) pp. e241-e245. ISSN 1079-2082 (2018) [Refereed Article]

Copyright Statement

Copyright 2018, American Society of Health-System Pharmacists, Inc.

DOI: doi:10.2146/ajhp170372

Abstract

Purpose: The stability of milrinone in continuous ambulatory delivery devices (CADDs) stored at 4, 25, and 35 C was evaluated.

Method: Six CADDs (3 devices containing milrinone plus 0.9% sodium chloride injection and 3 devices containing milrinone plus 5% dextrose injection) were prepared. Devices were kept at 4 C for 168 hours, followed by 24 hours at 25 C and an additional 24 hours at 35 C. Samples (n = 3) were withdrawn aseptically at 0, 24, 48, 72, 96, 120, 144, and 168 hours from the CADDs stored at 4 C and at 0, 6, and 24 hours from the CADDs stored at 25 and 35 C. The milrinone concentration of each aliquot was analyzed using a stability-indicating high performance liquid chromatographic method within 1530 minutes of preparation. The samples were also evaluated for changes in pH, changes in color, and particulate content. Six control samples (3 containing 0.9% sodium chloride injection and 3 containing 5% dextrose injection) were prepared and similarly analyzed.

Results: Milrinone admixtures retained more than 99% of their initial concentration for 168 hours at 4 C and for 24 hours when stored at 25 and 35 C. No evidence of particle formation, color change, or pH change was observed throughout the study period.

Conclusion: Milrinone 600 mg/mL prepared in either 0.9% sodium chloride injection or 5% dextrose injection in CADDs was stable for 168 hours when stored at 4 C and for 24 hours when stored at 25 and 35 C.

Item Details

Item Type:Refereed Article
Keywords:Stability, HPLC, Milrinone, CADD
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Primary Health Care
Objective Division:Health
Objective Group:Health and Support Services
Objective Field:Carer Health
UTAS Author:Al Madfai, F (Mrs Farah Al Madfai)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
UTAS Author:Ming, LC (Dr Long Ming)
UTAS Author:Wanandy, T (Mr Troy Wanandy)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:131794
Year Published:2018
Deposited By:Pharmacy
Deposited On:2019-04-06
Last Modified:2019-05-06
Downloads:0

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