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Polymethoxyflavones from Nicotiana plumbaginifolia (Solanaceae) exert antinociceptive and neuropharmacological effects in mice


Shajib, MS and Rashid, RB and Ming, LC and Islam, S and Sarker, MMR and Nahar, L and Sarker, SD and Datta, BK and Rashid, MA, Polymethoxyflavones from Nicotiana plumbaginifolia (Solanaceae) exert antinociceptive and neuropharmacological effects in mice, Frontiers in Pharmacology, 9 pp. 1-17. ISSN 1663-9812 (2018) [Refereed Article]


Copyright Statement

Copyright 2018 Shajib, Rashid, Ming, Islam, Sarker, Nahar, Sarker, Datta and Rashid. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fphar.2018.00085


Polymethoxylavones (PMFs) are known to exhibit significant anti-inflammatory and neuroprotective properties. Nicotiana plumbaginifolia, an annual Bangladeshi herb, is rich in polymethoxyflavones that possess significant analgesic and anxiolytic activities. The present study aimed to determine the antinociceptive and neuropharmacological activities of polyoxygenated flavonoids namely- 3,3′ ,5,6,7, 8-hexamethoxy-4′ ,5′ -methylenedioxyflavone (1), 3,3′ ,4′ ,5′ ,5,6,7,8-octamethoxyflavone (exoticin) (2), 6,7,4′ ,5′ -dimethylenedioxy-3,5,3′ -trimethoxyflavone (3), and 3,3′ ,4′ ,5,5′ , 8-hexamethoxy-6,7-methylenedioxyflavone (4), isolated and identified from N. plumbaginifolia. Antinociceptive activity was assessed using the acetic-acid induced writhing, hot plate, tail immersion, formalin and carrageenan-induced paw edema tests, whereas neuropharmacological effects were evaluated in the hole cross, open field and elevated plus maze test. Oral treatment of compounds 1, 3, and 4 (12.525 mg/kg b.w.) exhibited dose-dependent and significant (p < 0.01) antinociceptive activity in the acetic-acid, formalin, carrageenan, and thermal (hot plate)-induced pain models. The association of ATP-sensitive K+ channel and opioid systems in their antinociceptive effect was obvious from the antagonist effect of glibenclamide and naloxone, respectively. These findings suggested central and peripheral antinociceptive activities of the compounds. Compound 1, 3, and 4 (12.5 mg/kg b.w.) demonstrated significant (p < 0.05) anxiolytic-like activity in the elevated plus-maze test, while the involvement of GABAA receptor in the action of compound 3 and 4 was evident from the reversal effects of flumazenil. In addition, compounds 1 and 4 (12.525 mg/kg b.w) exhibited anxiolytic activity without altering the locomotor responses. The present study suggested that the polymethoxyflavones (14) from N. Plumbaginifolia could be considered as suitable candidates for the development of analgesic and anxiolytic agents.

Item Details

Item Type:Refereed Article
Keywords:nicotiana plumbaginifolia, polymethoxyflavone, antinociceptive, opioid, anxiolytic, benzodiazepine
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Ming, LC (Dr Long Ming)
ID Code:131693
Year Published:2018
Web of Science® Times Cited:12
Deposited By:Pharmacy
Deposited On:2019-04-01
Last Modified:2019-05-03
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