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Feasibility and normal ranges of arterial intima-media thickness and stiffness in 2-year-old children: a pilot study
Citation
Zhao, B and Johnston, FH and Dalton, M and Negishi, K, Feasibility and normal ranges of arterial intima-media thickness and stiffness in 2-year-old children: a pilot study, Pediatric Cardiology, 40, (5) pp. 914-920. ISSN 0172-0643 (2019) [Refereed Article]
Copyright Statement
Copyright 2019 Springer Science+Business Media, LLC, part of Springer Nature
DOI: doi:10.1007/s00246-019-02088-1
Abstract
Methods: Carotid intima-media thickness (cIMT) and abdominal aorta IMT (aaIMT), pulse wave velocity (PWV), arterial diameter change, stiffness index (β), and distensibility were assessed in 2-year-old children. IMT was assessed using an automatic contour detection.
Results: The proportion of successful measurements was 72% (42/58) with cIMT 64%, aaIMT 67%, and PWV 43%. Average far wall cIMT was 0.51 mm and 0.40 for aaIMT. Mean PWV was 4.15 m/s, with relatively wider range in stiffness index and distensibility. Common carotid arteries had a higher mean distensibility of 4.58%/10 mmHg compared with 2.98%/10 mmHg for the abdominal aorta. The number of data points automatically detected at far wall cIMT was higher than that in aaIMT (left cIMT: 244 ± 13 and right: 240 ± 23 vs. abdominal 185 ± 63, p < 0.001). Better and more consistent quality was achieved for cIMT than aaIMT measurements. PWV measurement was only feasible in cooperative children with efficient distractions.
Conclusions: Noninvasive methods for early detection of cardiovascular risks were feasible in at least two-thirds of 2-year-old children. Given the greater feasibility and image quality, cIMT is a preferable option for assessing vascular health in young children.
Item Details
Item Type: | Refereed Article |
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Keywords: | arterial stiffness, children, intima-media thickness, pulse wave velocity |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Zhao, B (Miss Bing Zhao) |
UTAS Author: | Johnston, FH (Associate Professor Fay Johnston) |
UTAS Author: | Dalton, M (Ms Marita Dalton) |
UTAS Author: | Negishi, K (Dr Kazuaki Negishi) |
ID Code: | 131618 |
Year Published: | 2019 |
Web of Science® Times Cited: | 5 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2019-03-27 |
Last Modified: | 2020-08-28 |
Downloads: | 0 |
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