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GABAB Receptors Regulate Extrasynaptic GABAA Receptors
Citation
Connelly, WM and Fyson, SJ and Errington, AC and McCafferty, CP and Cope, DW and Di Giovanni, G and Crunelli, V, GABAB Receptors Regulate Extrasynaptic GABAA Receptors, Journal of Neuroscience, 33, (9) pp. 3780-3785. ISSN 0270-6474 (2013) [Refereed Article]
Copyright Statement
Copyright 2013 the Authors
DOI: doi:10.1523/JNEUROSCI.4989-12.2013
Abstract
Tonic inhibitory GABAA receptor mediated currents are observed in numerous cell types in the CNS including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells and cerebellar granule cells. Here we show that in rat brain slices activation of postsynaptic GABABreceptors enhances the magnitude of the tonic GABAA current recorded in these cell types via a pathway involving Gi/o G-proteins, adenylate cyclase and cAMP-dependent protein kinase (PKA). Using a combination of pharmacology and knockout mice, we show that this pathway is independent of potassium channels or GABA transporters. Furthermore, the enhancement in tonic current is sufficient to significantly alter the excitability of thalamocortical neurons. These results demonstrate for the first time a postsynaptic cross talk between GABAB and GABAA receptors.
Item Details
Item Type: | Refereed Article |
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Keywords: | GABA receptors |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Cellular nervous system |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Connelly, WM (Dr William Connelly) |
ID Code: | 131563 |
Year Published: | 2013 |
Web of Science® Times Cited: | 57 |
Deposited By: | Medicine |
Deposited On: | 2019-03-22 |
Last Modified: | 2019-05-20 |
Downloads: | 0 |
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