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Metabotropic regulation of extrasynaptic GABAA receptors


Connelly, WM and Errington, AC and Di Giovanni, G and Crunelli, V, Metabotropic regulation of extrasynaptic GABAA receptors, Frontiers in neural circuits, 7 pp. 1-8. ISSN 1662-5110 (2013) [Refereed Article]


Copyright Statement

Copyright 2013 Connelly, Errington, Di Giovanni and Crunelli. Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0)

DOI: doi:10.3389/fncir.2013.00171


A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under regulation. Here we review the mechanisms by which tonic inhibition is known to be modulated, and outline the potential behavioral consequences of this modulation. Specifically, we address the ability of protein kinase A and C to phosphorylate the extrasynaptic receptors responsible for the tonic GABAA current, and how G-protein coupled receptors can regulate tonic inhibition through these effectors. We then speculate about the possible functional consequences of regulating the magnitude of the tonic GABAA current.

Item Details

Item Type:Refereed Article
Keywords:GABA receptors
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Connelly, WM (Dr William Connelly)
ID Code:131562
Year Published:2013
Web of Science® Times Cited:31
Deposited By:Medicine
Deposited On:2019-03-22
Last Modified:2019-04-26
Downloads:37 View Download Statistics

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