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The Thalamus as a Low Pass Filter: Filtering at the Cellular Level does Not Equate with Filtering at the Network Level

Citation

Connelly, WM and Laing, M and Errington, AC and Crunelli, V, The Thalamus as a Low Pass Filter: Filtering at the Cellular Level does Not Equate with Filtering at the Network Level, Frontiers in neural circuits, 9 Article 89. ISSN 1662-5110 (2016) [Refereed Article]


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Copyright Statement

Copyright 2016 Connelly, Laing, Errington and Crunelli. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fncir.2015.00089

Abstract

In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiological parameters, we show that the thalamus behaves akin to a low pass filter. Specifically, as individual cells in the thalamus rely on consistent drive to spike, stimuli that is rapidly and continuously changing over time such that it activates sensory cells with different receptive fields are unable to drive thalamic spiking. This means that thalamic encoding is robust to sensory noise, however it induces a lag in sensory representation. Thus, the thalamus stabilizes encoding of sensory information, at the cost of response rate.

Item Details

Item Type:Refereed Article
Keywords:Neuronal Filtering
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
UTAS Author:Connelly, WM (Dr William Connelly)
ID Code:131556
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Medicine
Deposited On:2019-03-22
Last Modified:2019-04-26
Downloads:3 View Download Statistics

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