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Pharmaceutical quality of antibiotics in Small Island Nations in the Western Pacific region: a pilot survey

Citation

Scrimgeour, S and Nunan, M and Sanburg, ALC and Jones, A and Narkowicz, C and Jacobson, GA and Schneider, JJ and McLachlan, AJ and Quilty, S, Pharmaceutical quality of antibiotics in Small Island Nations in the Western Pacific region: a pilot survey, Journal of Pharmacy Practice and Research, 49, (5) pp. 426-432. ISSN 1445-937X (2019) [Refereed Article]

Copyright Statement

Copyright 2019 The Society of Hospital Pharmacists of Australia

Official URL: https://onlinelibrary.wiley.com/journal/20552335

DOI: doi:10.1002/jppr.1540

Abstract

Background: Australia’s closest neighbours in the Western Pacific face many procurement, distribution and regulatory challenges providing patients with quality pharmaceuticals on limited budgets. This study tested the hypothesis that some antibiotics being used within the healthcare systems of Papua New Guinea, Vanuatu and the Solomon Islands were substandard, and through this pilot project explored challenges and constraints around collaborative regional pharmaceutical quality testing opportunities.

Methods: A list of 11 commonly used and ‘essential’ acute care intravenous and oral antibiotic products was compiled. A purposive sample of 20 units of each listed medicine was collected at the earliest possible point of the supply chain within the three participating nations. These samples were transported to Australia for analysis.

Results: All oral and intravenous product samples complied with uniformity of mass standards, except for oral amoxicillin from Country 3. Most antibiotics showed uniformity of content except for cloxacillin.

Conclusion: Most samples met quality standards, except for cloxacillin, which failed dramatically and this may indicate increased susceptibility to degradation in tropical settings. Although the results are reassuring compared with recent studies of pharmaceutical quality in this region, products of substandard quality were identified. The issues encountered in the timely testing of samples demonstrate the need for innovative solutions to promote pharmaceutical quality assurance, particularly in resource-limited settings. Strategic regional cooperation could greatly increase testing capability for Small Island Nations, benefiting the most vulnerable populations and strengthening antibiotic stewardship across the region.

Item Details

Item Type:Refereed Article
Keywords:quality assurance, pharmaceutical quality, supply chain, antibiotics, essential medicines, drug stability, pacific islands
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Pharmacology and Pharmaceutical Sciences not elsewhere classified
Objective Division:Manufacturing
Objective Group:Human Pharmaceutical Products
Objective Field:Human Pharmaceutical Treatments (e.g. Antibiotics)
UTAS Author:Narkowicz, C (Dr Christian Narkowicz)
UTAS Author:Jacobson, GA (Associate Professor Glenn Jacobson)
ID Code:131535
Year Published:2019
Deposited By:Pharmacy
Deposited On:2019-03-21
Last Modified:2020-03-26
Downloads:0

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