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Calcium signaling in brain cancers: roles and therapeutic targeting


Maklad, AA and Sharma, A and Azimi, I, Calcium signaling in brain cancers: roles and therapeutic targeting, Cancers, 11, (2) Article 145. ISSN 2072-6694 (2019) [Refereed Article]


Copyright Statement

Copyright 2019 The Author(s) Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3390/cancers11020145


Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation, therapy resistance and metastatic-related processes. In many cases, this is associated with altered expression and/or activity of some calcium channels and pumps. Brain cancers have also been the subject of many of these studies. In addition to diverse roles of calcium signals in normal brain function, a number of proteins involved in calcium transport are implicated to have specific roles in some brain cancers including gliomas, medulloblastoma, neuroblastoma and meningioma. This review discusses research that has been conducted so far to understand diverse roles of Ca2+-transporting proteins in the progression of brain cancers, as well as any attempts to target these proteins towards a therapeutic approach for the control of brain cancers. Finally, some knowledge gaps in the field that may need to be further considered are also discussed.

Item Details

Item Type:Refereed Article
Keywords:brain cancer, calcium signalling, therapeutic targeting
Research Division:Biological Sciences
Research Group:Biochemistry and cell biology
Research Field:Cell neurochemistry
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Maklad, AA (Mr Ahmed Maklad)
UTAS Author:Sharma, A (Dr Archna Sharma)
UTAS Author:Azimi, I (Dr Iman Azimi)
ID Code:131532
Year Published:2019
Web of Science® Times Cited:32
Deposited By:Pharmacy
Deposited On:2019-03-21
Last Modified:2020-12-18
Downloads:23 View Download Statistics

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