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Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults


Balogun, S and Winzenberg, T and Wills, K and Scott, DS and Jones, G and Callisaya, ML and Aitken, D, Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults, Experimental Gerontology, 118 pp. 65-71. ISSN 0531-5565 (2019) [Refereed Article]

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Copyright Statement

Copyright 2019 Elsevier Inc.

DOI: doi:10.1016/j.exger.2019.01.008


Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults.

Methods: Participants (N = 1002; 51% women; mean age 63  7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years.

Results: Participants with LMSLOW (β = -0.061, 95% CI: -0.089, -0.033) and women (β = -0.089, 95% CI: -0.129, -0.049) but not men (β = -0.023, 95% CI: -0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = -0.038, 95% CI: -0.068, -0.008).

Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.

Item Details

Item Type:Refereed Article
Keywords:body composition, health-related quality of life, muscle mass, muscle strength
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Geriatrics and gerontology
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Balogun, S (Dr Saliu Balogun)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Wills, K (Dr Karen Wills)
UTAS Author:Scott, DS (Mr David Scott)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Callisaya, ML (Dr Michele Callisaya)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
ID Code:131528
Year Published:2019
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-03-21
Last Modified:2020-03-05
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