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Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample

Citation

Liu, E and Kaidonis, G and Gillies, MC and Abhary, S and Essex, RW and Chang, JH and Pal, B and Daniell, M and Lake, S and Gilhotra, J and Petrovsky, N and Hewitt, AW and Jenkins, A and Lamoureux, EL and Gleadle, JM and Burdon, KP and Craig, JE, Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample, Scientific Reports, 9, (1) Article 612. ISSN 2045-2322 (2019) [Refereed Article]


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Copyright 2019 the authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1038/s41598-018-37388-8

Abstract

Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
UTAS Author:Burdon, KP (Professor Kathryn Burdon)
ID Code:131517
Year Published:2019
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-03-21
Last Modified:2019-04-08
Downloads:6 View Download Statistics

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