Balogun, S and Winzenberg, T and Wills, K and Scott, D and Callisaya, M and Cicuttini, F and Jones, G and Aitken, D, Prospective associations of osteosarcopenia and osteodynapenia with incident fracture and mortality over 10 years in community-dwelling older adults, Archives of Gerontology and Geriatrics, 82 pp. 67-73. ISSN 0167-4943 (2019) [Refereed Article]
Copyright 2019 Elsevier B.V.
Methods: 1032 participants (52% women; mean age 62.9 ± 7.4 years) were prospectively followed for 10 years. Mortality was ascertained from the death registry and fractures were self-reported. Baseline appendicular lean mass (ALM) was assessed using dual-energy X-ray absorptiometry and normalised to body mass index (BMI). Hand grip strength (HGS) was assessed by dynamometer. Osteosarcopenia and osteodynapenia were defined as having T-scores of the total hip and/or lumbar spine bone mineral density (BMD) < -1 combined with being in the lowest 20% of the sex-specific distribution for ALM/BMI or HGS respectively.
Results: Incident fracture risk was significantly higher in participants who were osteodynapenic (RR = 2.07, 95% CI: 1.26-3.39), dynapenic alone (RR = 1.74, 95% CI: 1.05-2.87), and osteopenic alone (RR = 1.63, 95% CI: 1.15-2.31), compared to those without dynapenia or osteopenia. Mortality risk was significantly higher only in participants with osteosarcopenia (RR = 1.49, 95% CI: 1.01-2.21) compared to those without sarcopenia or osteopenia. However, osteosarcopenia and osteodynapenia did not lead to a significantly greater fracture or mortality risk compared to having these conditions on their own.
Conclusion: These findings suggest that the combined effect of osteopenia and sarcopenia or dynapenia on fracture and mortality risk, respectively, may not be greater than that of each individual condition.
|Item Type:||Refereed Article|
|Keywords:||dynapenia, fracture, mortality, osteopenia, osteoporosis, sarcopenia|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|UTAS Author:||Balogun, S (Dr Saliu Balogun)|
|UTAS Author:||Winzenberg, T (Professor Tania Winzenberg)|
|UTAS Author:||Wills, K (Dr Karen Wills)|
|UTAS Author:||Scott, D (Mr David Scott)|
|UTAS Author:||Callisaya, M (Dr Michele Callisaya)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Aitken, D (Associate Professor Dawn Aitken)|
|Deposited By:||Menzies Institute for Medical Research|
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