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Epigenetic age acceleration in adolescence associates with BMI, inflammation and risk score for middle age cardiovascular disease


Huang, RC and Lillycrop, KA and Beilin, LJ and Godfrey, KM and Anderson, D and Mori, TA and Rauschert, S and Craig, JM and Oddy, WH and Ayonrinde, OT and Pennell, CE and Holbrook, JD and Melton, PE, Epigenetic age acceleration in adolescence associates with BMI, inflammation and risk score for middle age cardiovascular disease, Journal of Clinical Endocrinology and Metabolism pp. 1-19. ISSN 0021-972X (2018) [Refereed Article]

Copyright Statement

Copyright 2019 The Journal of Clinical Endocrinology & Metabolism

DOI: doi:10.1210/jc.2018-02076


Background: 'Accelerated ageing', assessed by adult DNA methylation predicts cardiovascular disease (CVD). Adolescent accelerated aging might predict CVD earlier. We investigated whether epigenetic age acceleration (assessed age 17-years) associated with adiposity/CVD-risk measured (ages 17, 20, 22-years), and projected CVD by middle-age.

Methods: DNA methylation measured in peripheral blood provided 2 estimates of epigenetic age acceleration; intrinsic (IEAA, (preserved across cell types) and extrinsic (EEAA, dependent on cell admixture and methylation levels within each cell type).Adiposity was assessed by anthropometry, ultrasound and DEXA (ages 17, 20, 22 years). CVD-risk factors (lipids, HOMA-IR, blood pressure, inflammatory markers) were assessed at age 17-years. CVD development by age 47 years was calculated by Framingham algorithms. Results are presented as regression coefficients/5-year epigenetic age acceleration (IEAA/EEAA) for adiposity, CVD-risk factors and CVD development.

Results: In 995 participants (49.6% female, age 17.3+/-0.6 years), EEAA (/5-years) was associated with increased BMI of 2.4% (95%CI 1.2-3.6%) and 2.4% (0.8-3.9%) at 17 and 22 years, respectively. EEAA was associated with increases of 23% (3-33%) in hsCRP, 10% (4-17%) in interferon-gamma induced protein (IP-10) and 4% (2-6%) in tumour necrosis factor receptor 2 (sTNFR2), adjusted for BMI and HOMA-IR. EEAA(/5-years) results in a 4% increase in hard endpoints of CVD by 47 years old and a 3% increase, after adjustment for conventional risk factors.

Conclusions: Accelerated epigenetic age in adolescence was associated with inflammation, BMI measured 5 years later, and probability of middle-age CVD. Irrespective whether this is cause or effect, assessing epigenetic age might refine disease prediction.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Nutrition and Dietetics
Research Field:Dietetics and Nutrigenomics
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Nutrition
UTAS Author:Oddy, WH (Professor Wendy Oddy)
ID Code:131502
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-03-20
Last Modified:2019-04-03

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