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Relationship between vitamin D status from childhood to early adulthood with body composition in young Australian adults

Citation

Zhu, K and Oddy, WH and Holt, P and Ping-Delfos, WCS and McVeigh, J and Straker, L and Mori, TA and Lye, S and Pennell, C and Walsh, JP, Relationship between vitamin D status from childhood to early adulthood with body composition in young Australian adults, Journal of the Endocrine Society, 3, (3) pp. 563-576. ISSN 2472-1972 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Endocrine Society

DOI: doi:10.1210/js.2018-00349

Abstract

Context: Vitamin D plays a role in the differentiation and metabolism of skeletal muscle and, possibly, adipose tissue; however, the relationship between vitamin D status during growth and body composition in early adulthood is unclear.

Objective: We examined associations between vitamin D status in childhood, adolescence, and early adulthood with body composition at age 20 years.

Design Setting Participants: We studied 821 offspring (385 females) of the Western Australian Pregnancy Cohort Study who had ≥3 serum 25-hydroxyvitamin D [25(OH)D] at age 6, 14, 17, and 20 years and body composition assessed at age 20 using dual-energy x-ray absorptiometry. The participants were grouped into four vitamin D status trajectories: consistently lower, decreasing, increasing, and consistently higher.

Results: The mean serum 25(OH)D at the study visits was 72.7 to 86.8 nmol/L. In males, serum 25(OH)D at 17 and 20 years was positively associated with lean body mass (LBM), and 25(OH)D at age 20 correlated negatively with fat body mass (FBM). Males with a consistently higher 25(OH)D trajectory had a 2.3- to 3.7-kg greater LBM and 4.1- to 6.0-kg lower FBM at 20 years compared with those with consistently lower or decreasing trajectories (P < 0.05 for all). In females, 25(OH)D at 14, 17, and 20 years was negatively associated with FBM. Females with increasing or consistently higher 25(OH)D trajectories had a 5.2- to 6.8-kg lower FBM at age 20 compared with those with a consistently lower trajectory (P < 0.05 for all).

Conclusions: In the present predominantly white, relatively vitamin D-replete cohort, a higher vitamin D status trajectory from childhood to early adulthood was associated with a greater LBM in males and lower FBM in both sexes at age 20.

Item Details

Item Type:Refereed Article
Keywords:25-hydroxyvitamin D, Raine study, body composition, fat body mass, lean body mass, young adults
Research Division:Medical and Health Sciences
Research Group:Nutrition and Dietetics
Research Field:Nutrition and Dietetics not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Nutrition
UTAS Author:Oddy, WH (Professor Wendy Oddy)
ID Code:131500
Year Published:2019
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-03-20
Last Modified:2019-04-08
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