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Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord


Schnerwitzki, D and Perry, S and Ivanova, A and Caixeta, FV and Cramer, P and Gunther, S and Weber, K and Tafreshiha, A and Becker, L and Vargas Panesso, IL and Klopstock, T and Hrabe de Angelis, M and Schmidt, M and Kullander, K and Englert, C, Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord, Life science alliance, 1, (4) pp. 1-15. ISSN 2575-1077 (2018) [Refereed Article]


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Copyright 2018 Schnerwitzki et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.26508/lsa.201800106


Locomotion is coordinated by neuronal circuits of the spinal cord. Recently, dI6 neurons were shown to participate in the control of locomotion. A subpopulation of dI6 neurons expresses the Wilms tumor suppressor gene Wt1. However, the function of Wt1 in these cells is not understood. Here, we aimed to identify behavioral changes and cellular alterations in the spinal cord associated with Wt1 deletion. Locomotion analyses of mice with neuron-specific Wt1 deletion revealed a slower walk with a decreased stride frequency and an increased stride length. These mice showed changes in their fore-/hindlimb coordination, which were accompanied by a loss of contralateral projections in the spinal cord. Neonates with Wt1 deletion displayed an increase in uncoordinated hindlimb movements and their motor neuron output was arrhythmic with a decreased frequency. The population size of dI6, V0, and V2a neurons in the developing spinal cord of conditional Wt1 mutants was significantly altered. These results show that the development of particular dI6 neurons depends on Wt1 expression and that loss of Wt1 is associated with alterations in locomotion.

Item Details

Item Type:Refereed Article
Keywords:CPG; WT1; central pattern generator; interneuron; locomotion
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
ID Code:131491
Year Published:2018
Web of Science® Times Cited:17
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2019-03-20
Last Modified:2019-07-30
Downloads:24 View Download Statistics

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