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NOx in exhaled breath condensate is related to allergic sensitization in young and middle‐aged adults


Aldakheel, FM and Bourke, JE and Thomas, PS and Matheson, MC and Abramson, MJ and Hamilton, GS and Lodge, CJ and Thompson, B and Walters, EH and Allen, KJ and Erbas, B and Perret, JL and Dharmage, SC and Lowe, AJ, NOx in exhaled breath condensate is related to allergic sensitization in young and middle‐aged adults, Clinical and Experimental Allergy, 49, (2) pp. 171-179. ISSN 0954-7894 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 John Wiley & Sons Ltd.

DOI: doi:10.1111/cea.13251


Background: Asthma and allergic diseases are heterogeneous. Measurement of biomarkers in exhaled breath condensate (EBC) may help to discriminate between different phenotypes and may assist with clinical prognostication.

Objectives: We aimed to assess associations between total nitric oxide products (NOx) in EBC and different allergic phenotypes and lung function in young and middle‐aged adults.

Methods: Cross‐sectional analyses were nested within two Australian longitudinal studies, the Melbourne Atopy Cohort Study (MACS, mean age 17.8 years) and the Tasmanian Longitudinal Health Study (TAHS, mean age 49.4 years). Levels of EBC NOx were determined by Griess‐reaction fluorescent method. Associations were assessed between EBC NOx and different allergic phenotypes, lung function and airway reactivity.

Results: Atopy, with or without asthma or rhinitis, was associated with increased EBC NOx levels particularly in individuals with poly‐aero‐sensitization. These findings were generally consistent across the two age groups. In the older cohort, use of ICS in the previous 12 months masked the association between sensitization and EBC NOx (OR = 0.64, 95% CI = 0.21‐1.96, p for interaction = 0.05).

Conclusions and clinical relevance: In these population‐based samples, EBC NOx was most strongly associated with atopic sensitization, rather than either current asthma or rhinitis, possibly indicating underlying increased airway inflammation associated with atopy. Therefore, EBC NOx could be a key predictor of atopy in both young and middle‐aged adults, regardless of the presence of concomitant asthma or rhinitis.

Item Details

Item Type:Refereed Article
Keywords:asthma, atopy, exhaled breath condensate, rhinitis, total nitric oxide
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:131476
Year Published:2018
Web of Science® Times Cited:8
Deposited By:Medicine
Deposited On:2019-03-19
Last Modified:2019-04-08

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