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Association of TLR7 gene copy number variations with ankylosing spondylitis in a Chinese population: a case control study

Citation

Wang, M and Xu, S and Zhang, X and Chen, M and Han, R and Hu, X and Yuan, Y and Ma, Y and Yang, J and Wu, M and Liu, R and Jiang, G and Pan, F, Association of TLR7 gene copy number variations with ankylosing spondylitis in a Chinese population: a case control study, Clinical and Experimental Rheumatology, 36, (5) pp. 814-819. ISSN 0392-856X (2018) [Refereed Article]

Copyright Statement

Copyright Clinical And Experimental Rheumatology 2018.

Abstract

Objectives: To explore the association of TLR7 gene copy number variations (CNVs) with the susceptibility of ankylosing spondylitis (AS).

Methods: The case control study was performed in 649 Chinese Han patients with AS and 628 healthy controls. The copy numbers of TLR7 gene (2 fragments) were measured by AccuCopyTM methods. Chi-square and logistic regression models were performed to investigate the association of TLR7 gene CNVs with AS. Odds ratio (ORs) and 95% confidence intervals (CIs) was calculated to estimate AS risk and the Bonferroni correction was applied owing to multiple testing.

Results: The logistic regression analysis showed that one copy was significantly associated with AS susceptibility after Bonferroni correction (for the TLR7_1 fragment: OR=1.458, 95%CI(1.098,1.936), p=0.009; for the TLR7_2 fragment: OR=1.451, 95%CI (1.093,1.927), p=0.010), and this association still exists after adjustment of age and sex (for the TLR7_1 fragment: adjusted OR=2.066, 95%CI (1.318,3.238), p=0.002; for the TLR7_2 fragment: adjusted OR=2.061, 95%CI (1.315,3.230), p=0.002). However, logistic regression analysis stratified by gender showed a higher OR in males (for the TLR7_1 fragment: OR(95%CI)=7.987(3.756,16.983); for the TLR7_2 fragment: OR(95%CI)=7.947(3.738,16.897)) than in females (for the TLR7_1 fragment: OR(95%CI)=0.204(0.080,0.524); for the TLR7_2 fragment: OR(95%CI)=0.204(0.080,0.524)).

Conclusions: We conclude that the lower copy number (=1) of TLR7 gene confers a risk factor for AS susceptibility in males but protective factor in females.

Item Details

Item Type:Refereed Article
Keywords:ankylosing spondylitis, copy number variations, TLR7, case control
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Pan, F (Professor Faming Pan)
ID Code:131474
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-03-19
Last Modified:2019-04-26
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