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Rod microglia and their role in neurological diseases

Citation

Holloway, OG and Canty, AJ and King, AE and Ziebell, JM, Rod microglia and their role in neurological diseases, Seminars in Cell and Developmental Biology, 94 pp. 96-103. ISSN 1084-9521 (2019) [Refereed Article]


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Copyright 2019 Elsevier Ltd.

DOI: doi:10.1016/j.semcdb.2019.02.005

Abstract

The striking morphology of microglia is one of their most prominent characteristics, with many studies categorising microglial function based on morphology e.g. ramified, hyper-ramified, activated, or amoeboid. Communications regarding rod microglia in neurological disease are scant, and where reported, these cells are rarely the focus of discussion. These factors make it difficult to determine how widespread these cells are not only through the brain but also across diseases. Studies in experimental diffuse brain injury are the first reports of not only significant numbers of rod microglia, but distinct arrangements of these cells, reminiscent of carriages of a train. This review summarises the available reports of rod microglia in vivo and rod-like microglia in vitro and eludes to possible functions and signalling cascades that may evoke this distinct morphology. More investigations are required to fully elucidate the function that rod microglia play in neurological diseases.

Item Details

Item Type:Refereed Article
Keywords:rod microglia, ageing, neurological disease, traumatic brain injury (TBI), neuroinflammation
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
UTAS Author:Holloway, OG (Miss Olivia Holloway)
UTAS Author:Canty, AJ (Associate Professor Alison Canty)
UTAS Author:King, AE (Professor Anna King)
UTAS Author:Ziebell, JM (Dr Jenna Ziebell)
ID Code:131418
Year Published:2019
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2019-03-18
Last Modified:2020-01-21
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