University of Tasmania
Browse

File(s) under permanent embargo

Investigational drugs for the treatment of osteoarthritis, an update on recent developments

journal contribution
posted on 2023-05-20, 01:44 authored by Zhu, Z, Li, J, Ruan, G, Wang, G, Huang, C, Chang-Hai DingChang-Hai Ding
Introduction: Osteoarthritis (OA) is the leading cause of pain, loss of function, and disability among elderly, with the knee the most affected joint. It is a heterogeneous condition characterized by complex and multifactorial etiologies which contribute to the broad variation in symptoms presentation and treatment responses that OA patients present. This poses a challenge for the development of effective treatment on OA.

Areas Covered: This review will discuss recent development of agents for the treatment of OA, updating our previous narrative review published in 2015. They include drugs for controlling local and systemic inflammation, regulating articular cartilage, targeting subchondral bone, and relieving pain.

Expert Opinion: Although new OA drugs such as monoclonal antibodies have shown marked effects and favorable tolerance, current treatment options for OA remain limited. The authors believe there is no miracle drug that can be used for all OA patients'; treatment and disease stage is crucial for the effectiveness of drugs. Therefore, early diagnosis, phenotyping OA patients and precise therapy would expedite the development of investigational drugs targeting at symptoms and disease progression of OA.

History

Publication title

Expert opinion on investigational drugs

Volume

27

Issue

11

Pagination

881-900

ISSN

1354-3784

Department/School

Menzies Institute for Medical Research

Publisher

Ashley Publications Ltd

Place of publication

Unitec House, 3Rd Fl, 2 Albert Place, Finchley Central, London, England, N3 1Qb

Rights statement

© 2018 Informa UK Limited, trading as Taylor & Francis Group

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC