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MACPF/CDC proteins in development: insights from Drosophila torso-like


Johnson, TK and Henstridge, MA and Warr, C, MACPF/CDC proteins in development: insights from Drosophila torso-like, Seminars in Cell and Developmental Biology, 72 pp. 163-170. ISSN 1084-9521 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 Elsevier Ltd.

DOI: doi:10.1016/j.semcdb.2017.05.003


The Membrane Attack Complex Perforin-like/Cholesterol-Dependent Cytolysin (MACPF) superfamily is an ancient and biologically diverse group of proteins that are best known for pore-forming roles in mammalian immunity and bacterial pathogenesis. Intriguingly, however, some eukaryotic proteins which contain the MACPF domain that defines this family do not act in attack or defence, and instead have distinct developmental functions. It remains unclear whether these proteins function via pore formation or have a different mechanism of action. Of these, by far the best characterised is Torso-like (Tsl), the only MACPF member that has been identified in the fruit fly, Drosophila melanogaster. While it has long been known to have a role in embryonic patterning, recent studies have shown that Tsl in fact has multiple roles in development. As such, it presents an excellent opportunity to investigate how the MACPF domain functions in a developmental context. Here, we review what is known about Tsl in Drosophila and other insects, and discuss the potential molecular mechanism by which Tsl and thus other developmental MACPF proteins may function. © 2017 Elsevier Ltd

Item Details

Item Type:Refereed Article
Keywords:Development; Drosophila; Growth; MACPF; Patterning; Torso-like; cholesterol dependent cytolysin; complement membrane attack complex; cytolysin; unclassified drug; cholesterol; complement membrane attack complex; cytotoxin; Drosophila protein; Review
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Developmental genetics (incl. sex determination)
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Warr, C (Professor Coral Warr)
ID Code:131328
Year Published:2017
Web of Science® Times Cited:7
Deposited By:Medicine
Deposited On:2019-03-13
Last Modified:2019-05-06

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