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Using mouse and Drosophila models to investigate the mechanistic links between diet, obesity, type II diabetes, and cancer

Citation

Warr, CG and Shaw, KH and Azim, A and Piper, MDW and Parsons, LM, Using mouse and Drosophila models to investigate the mechanistic links between diet, obesity, type II diabetes, and cancer, International Journal of Molecular Sciences, 19, (12) Article 4110. ISSN 1661-6596 (2018) [Refereed Article]


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Copyright Statement

2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

DOI: doi:10.3390/ijms19124110

Abstract

Many of the links between diet and cancer are controversial and over simplified. To date, human epidemiological studies consistently reveal that patients who suffer diet-related obesity and/or type II diabetes have an increased risk of cancer, suffer more aggressive cancers, and respond poorly to current therapies. However, the underlying molecular mechanisms that increase cancer risk and decrease the response to cancer therapies in these patients remain largely unknown. Here, we review studies in mouse cancer models in which either dietary or genetic manipulation has been used to model obesity and/or type II diabetes. These studies demonstrate an emerging role for the conserved insulin and insulin-like growth factor signaling pathways as links between diet and cancer progression. However, these models are time consuming to develop and expensive to maintain. As the world faces an epidemic of obesity and type II diabetes we argue that the development of novel animal models is urgently required. We make the case for Drosophila as providing an unparalleled opportunity to combine dietary manipulation with models of human metabolic disease and cancer. Thus, combining diet and cancer models in Drosophila can rapidly and significantly advance our understanding of the conserved molecular mechanisms that link diet and diet-related metabolic disorders to poor cancer patient prognosis.

Item Details

Item Type:Refereed Article
Keywords:cancer, diet, obesity, type II diabetes mellitus, Drosophila
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Developmental genetics (incl. sex determination)
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Warr, CG (Professor Coral Warr)
ID Code:131311
Year Published:2018
Web of Science® Times Cited:8
Deposited By:Medicine
Deposited On:2019-03-13
Last Modified:2019-12-03
Downloads:9 View Download Statistics

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