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Genome-wide linkage scan for loci influencing plasma triglyceride levels

Citation

Peralta, JM and Blackburn, NB and Porto, A and Blangero, J and Charlesworth, J, Genome-wide linkage scan for loci influencing plasma triglyceride levels, BMC Proceedings, 12, (Suppl 9) Article 52. ISSN 1753-6561 (2018) [Refereed Article]


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Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/s12919-018-0137-6

Abstract

We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-fenofibrate intervention. Multipoint identity-by-descent (MIBD) matrices were derived from genotypes using IBDLD. Variance-component linkage analyses were then conducted using SOLAR (Sequential Oligogenic Linkage Analysis Routines). We found evidence of linkage (logarithm of odds [LOD] ≥3) at 5 chromosomal regions with triglyceride levels in plasma. The highest LOD scores were observed for linkage to the estimated genetic value (additive genetic component) of the log-normalized triglyceride levels in plasma. Our results suggest that a chromosome 10 locus at 37 cM (LODpre = 3.01, LODpost = 3.72) influences fasting triglyceride levels in plasma regardless of the fenofibrate intervention, and that loci in chromosomes 1 at 170 cM and 4 at 24 cM ceases to affect the triglyceride levels when fenofibrate is present, while the regions in chromosomes 6 at 136 to 162 cM and 11 at 39 to 40 cM appear to influence triglyceride levels in response to fenofibrate.

Item Details

Item Type:Refereed Article
Keywords:linkage analysis, triglycerides, Genetic Analysis Workshop 20, GAW20
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genomics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Blackburn, NB (Dr Nicholas Blackburn)
UTAS Author:Blangero, J (Professor John Blangero)
UTAS Author:Charlesworth, J (Dr Jac Charlesworth)
ID Code:130925
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-02-20
Last Modified:2019-03-18
Downloads:75 View Download Statistics

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