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No evidence of white adipocyte browning after endurance exercise training in obese men

Citation

Tsiloulis, T and Carey, AL and Bayliss, J and Canny, B and Meex, RCR and Watt, MJ, No evidence of white adipocyte browning after endurance exercise training in obese men, International Journal of Obesity, 42, (4) pp. 721-727. ISSN 0307-0565 (In Press) [Refereed Article]


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Copyright Statement

Copyright 2017 Macmillan Publishers Limited.

DOI: doi:10.1038/ijo.2017.295

Abstract

Background/Objectives: The phenomenon of adipocyte ‘beiging’ involves the conversion of non-classic brown adipocytes to brown-like adipose tissue with thermogenic, fat-burning properties, and this phenomenon has been shown in rodents to slow the progression of obesity-associated metabolic diseases. Rodent studies consistently report adipocyte beiging after endurance exercise training, indicating that increased thermogenic capacity in these adipocytes may underpin the improved health benefits of exercise training. The aim of this study was to determine whether prolonged endurance exercise training induces beige adipogenesis in subcutaneous adipose tissues of obese men.

Subjects/Methods: Molecular markers of beiging were examined in adipocytes obtained from abdominal subcutaneous (AbSC) and gluteofemoral (GF) subcutaneous adipose tissues before and after 6 weeks of endurance exercise training in obese men (n=6, 37.3±2.3 years, 30.1±2.3 kg m–2).

Results: The mRNAs encoding the brown or beige adipocyte-selective proteins were very lowly expressed in AbSC and GF adipose tissues and exercise training did not alter the mRNA expression of UCP1, CD137, CITED, TBX1, LHX8 and TCF21. Using immunohistochemistry, neither multilocular adipocytes, nor UCP1 or CD137-positive adipocytes were detected in any sample. MicroRNAs known to regulate brown and/or beige adipose development were highly expressed in white adipocytes but endurance exercise training did not impact their expression.

Conclusions: The present study reaffirms emerging data in humans demonstrating no evidence of white adipose tissue beiging in response to exercise training, and supports a growing body of work demonstrating divergence of brown/beige adipose location, molecular characterization and physiological function between rodents and humans.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Human Movement and Sports Science
Research Field:Exercise Physiology
Objective Division:Health
Objective Group:Specific Population Health (excl. Indigenous Health)
Objective Field:Men's Health
UTAS Author:Canny, B (Professor Ben Canny)
ID Code:130914
Year Published:In Press
Deposited By:Medicine
Deposited On:2019-02-20
Last Modified:2019-03-20
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