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Childhood measles contributes to post-bronchodilator airflow obstruction in middle-aged adults: a cohort study

Citation

Perret, JL and Matheson, MC and Gurrin, LC and Johns, DP and Burgess, JA and Thompson, BR and Lowe, AJ and Markos, J and Morrison, SS and McDonald, CF and Wood-Baker, R and Svanes, C and Thomas, PS and Hopper, JL and Giles, GG and Abramson, MJ and Walters, EH and Dharmage, SC, Childhood measles contributes to post-bronchodilator airflow obstruction in middle-aged adults: a cohort study, Respirology, 23, (8) pp. 780-787. ISSN 1323-7799 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Asian Pacific Society of Respirology

DOI: doi:10.1111/resp.13297

Abstract

Background and objective: Chronic obstructive pulmonary disease (COPD) has potential origins in childhood but an association between childhood measles and postbronchodilator (BD) airflow obstruction (AO) has not yet been shown. We investigated whether childhood measles contributed to post-BD AO through interactions with asthma and/or smoking in a non-immunized middle-aged population.

Methods: The population-based Tasmanian Longitudinal Health Study (TAHS) cohort born in 1961 (n = 8583) underwent spirometry in 1968 before immunization was introduced. A history of childhood measles infection was obtained from school medical records. During the fifth decade follow-up (n = 5729 responses), a subgroup underwent further lung function measurements (n = 1389). Relevant main associations and interactions by asthma and/or smoking on post-BD forced expiratory volume in 1 s/forced vital capacity (FEV1/ FVC; continuous variable) and AO (FEV1/FVC < lower limit of normal) were estimated by multiple regression.

Results: Sixty‐nine percent (n = 950) had a history of childhood measles. Childhood measles augmented the combined adverse effect of current clinical asthma and smoking at least 10 pack‐years on post‐BD FEV1/FVC ratio in middle age (z‐score: −0.70 (95% CI: −1.1 to −0.3) vs −1.36 (−1.6 to −1.1), three‐way interaction: P = 0.009), especially for those with childhood‐onset asthma. For never‐ and ever‐smokers of <10 pack‐years who had current asthma symptoms, compared with those without childhood measles, paradoxically, the odds for post‐BD AO was not significant in the presence of childhood measles (OR: 12.0 (95% CI: 3.442) vs 2.17 (0.95.3)).

Conclusion: Childhood measles infection appears to compound the associations between smoking, current asthma and post-BD AO. Differences between asthma subgroups provide further insight into the complex aetiology of obstructive lung diseases for middle-aged adults.

Item Details

Item Type:Refereed Article
Keywords:asthma-COPD overlap, childhood measles, current adult asthma, interaction, smoking
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Johns, DP (Associate Professor David Johns)
UTAS Author:Wood-Baker, R (Professor Richard Wood-Baker)
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:130911
Year Published:2018
Web of Science® Times Cited:1
Deposited By:Medicine
Deposited On:2019-02-20
Last Modified:2019-04-26
Downloads:0

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