May, T and Pridmore, S, Impact of transcranial magnetic stimulation on the symptom profile of major depressive episode, Australasian Psychiatry pp. 1-5. ISSN 1039-8562 (2019) [Refereed Article]
Objectives: This study aimed to explore the effects of a four-week course of transcranial magnetic stimulation (TMS) on the following symptoms of major depressive episode (MDE): mood, work activities, health concerns, guilt, anxiety and retardation.
Method: Patients underwent 20 daily sessions of 10 Hz TMS (two sets of 10 daily treatments separated by two days of rest). The six-item Hamilton Depression Rating Scale (HAMD-6) was administered before and after treatment. Remission was operationalised as a HAMD-6 score of <4. Descriptive statistics and t-tests were used to compare pre/ post scores on HAMD-6 subscales, and logistic regression was used to understand symptoms that predicted remission/ non-remission.
Results: There were 104 participants (79 female; 76%), with a mean age of 44.6 years (SD=15.7 years). There was a significant improvement in the whole sample and in remitters (n=70) on all subscales. However, those who failed to remit did not achieve significant reductions in ‘health concerns’ and ‘retardation’. There were no difference in age and sex between remitters and non-remitters. Also, there were no significant differences between the remitters and non-remitters on the pretreatment depression symptom profiles. No predictors of response were identified, as expected.
Conclusions: TMS has the ability to reduce all listed MDE symptoms. No pretreatment MDE symptom profile was identified which might carry prognostic value.
|Item Type:||Refereed Article|
|Keywords:||major depressive disorder, transcranial magnetic stimulation, symptom profile, Hamilton Depression Rating Scale|
|Research Division:||Health Sciences|
|Research Group:||Health services and systems|
|Research Field:||Mental health services|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Mental health|
|UTAS Author:||Pridmore, S (Professor Saxby Pridmore)|
|Web of Science® Times Cited:||3|
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