Sim, EHA and Yang, IA and Wood-Baker, R and Bowman, RV and Fong, KM, Gefitinib for advanced non-small cell lung cancer, Cochrane Database of Systematic Reviews, 2018, (1) Article CD006847. ISSN 1469-493X (2018) [Refereed Article]
Copyright © 2018 The Cochrane Collaboration.
Background: The role of gefitinib for the treatment of advanced non-small cell lung cancer (NSCLC) is evolving. We undertook a systematic review to evaluate the available evidence from all randomised trials.
Objectives: To determine the effectiveness and safety of gefitinib as first-line, second-line or maintenance treatment for advanced NSCLC.
Search methods: We performed searches in CENTRAL, MEDLINE and Embase from inception to 17 February 2017. We handsearched relevant conference proceedings, clinical trial registries and references lists of retrieved articles.
Selection criteria: We included trials assessing gefitinib, alone or in combination with other treatment, compared to placebo or other treatments in the first- or successive-line treatment of patients with NSCLC, excluding compassionate use.
Data collection and analysis: We used the standard Cochrane methodology. Two authors independently assessed the search results to select those with sound methodological quality. We carried out all analyses on an intention-to-treat basis. We recorded the following outcome data: overall survival, progression-free survival, toxicity, tumour response and quality of life. We also collected data for the following subgroups: Asian ethnicity and positive epidermal growth factor receptor (EGFR) mutation.
Main results: We included 35 eligible randomised controlled trials (RCTs), which examined 12,089 patients.
|Item Type:||Refereed Article|
|Keywords:||getfitnib, non-small lung cancer, NSCLC|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Oncology and carcinogenesis|
|Research Field:||Cancer therapy (excl. chemotherapy and radiation therapy)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Wood-Baker, R (Professor Richard Wood-Baker)|
|Web of Science® Times Cited:||29|
|Deposited By:||Health Sciences|
|Downloads:||114 View Download Statistics|
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