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130883 - Gefitinib for advanced non-small cell lung cancer.pdf (2.04 MB)

Gefitinib for advanced non-small cell lung cancer

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posted on 2023-05-20, 00:58 authored by Sim, EHA, Yang, IA, Wood-Baker, R, Bowman, RV, Fong, KM

Background: The role of gefitinib for the treatment of advanced non-small cell lung cancer (NSCLC) is evolving. We undertook a systematic review to evaluate the available evidence from all randomised trials.

Objectives: To determine the effectiveness and safety of gefitinib as first-line, second-line or maintenance treatment for advanced NSCLC.

Search methods: We performed searches in CENTRAL, MEDLINE and Embase from inception to 17 February 2017. We handsearched relevant conference proceedings, clinical trial registries and references lists of retrieved articles.

Selection criteria: We included trials assessing gefitinib, alone or in combination with other treatment, compared to placebo or other treatments in the first- or successive-line treatment of patients with NSCLC, excluding compassionate use.

Data collection and analysis: We used the standard Cochrane methodology. Two authors independently assessed the search results to select those with sound methodological quality. We carried out all analyses on an intention-to-treat basis. We recorded the following outcome data: overall survival, progression-free survival, toxicity, tumour response and quality of life. We also collected data for the following subgroups: Asian ethnicity and positive epidermal growth factor receptor (EGFR) mutation.

Main results: We included 35 eligible randomised controlled trials (RCTs), which examined 12,089 patients.

History

Publication title

Cochrane Database of Systematic Reviews

Volume

2018

Article number

CD006847

Number

CD006847

Pagination

1-265

ISSN

1469-493X

Department/School

Tasmanian School of Medicine

Publisher

Vista

Place of publication

United Kingdom

Rights statement

Copyright © 2018 The Cochrane Collaboration.

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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