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Lactobacillus acidophilus DDS-1 modulates the gut microbiota and improves metabolic profiles in aging mice
Citation
Vemuri, R and Shinde, TS and Gundamaraju, R and Gondalia, SV and Karpe, AV and Beale, DJ and Martoni, CJ and Eri, R, Lactobacillus acidophilus DDS-1 modulates the gut microbiota and improves metabolic profiles in aging mice, Nutrients, 10, (9) Article 1255. ISSN 2072-6643 (2018) [Refereed Article]
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Copyright Statement
Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Abstract
Recent evidence suggests that gut microbiota shifts can alter host metabolism even during healthy aging. Lactobacillus acidophilus DDS-1, a probiotic strain, has shown promising probiotic character in vitro, as well as in clinical studies. The present study was carried out to investigate whether DDS-1 can modulate the host metabolic phenotype under the condition of age-affected gut microbial shifts in young and aging C57BL/6J mice. Collected fecal samples were analyzed using 16S rRNA gene sequencing for identifying gut microbiota and untargeted gas chromatography-mass spectrometry (GC-MS) metabolomics analysis. Gut microbial shifts were observed in the control groups (young and aging), leading to an alteration in metabolism. Principal coordinate analysis (PCoA) of microbiota indicated distinct separation in both the DDS-1-treated groups. L. acidophilus DDS-1 increased the relative abundances of beneficial bacteria, such as Akkermansia muciniphila and Lactobacillus spp., and reduced the relative levels of opportunistic bacteria such as Proteobacteria spp. Metabolic pathway analysis identified 10 key pathways involving amino acid metabolism, protein synthesis and metabolism, carbohydrate metabolism, and butanoate metabolism. These findings suggest that modulation of gut microbiota by DDS-1 results in improvement of metabolic phenotype in the aging mice.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | aging, gut microbiota, metabolism, probiotics |
| Research Division: | Biological Sciences |
| Research Group: | Biochemistry and cell biology |
| Research Field: | Cell metabolism |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the health sciences |
| UTAS Author: | Vemuri, R (Mr Ravichandra Vemuri) |
| UTAS Author: | Shinde, TS (Ms Tanvi Shinde) |
| UTAS Author: | Gundamaraju, R (Mr Rohit Gundamaraju) |
| UTAS Author: | Eri, R (Associate Professor Raj Eri) |
| ID Code: | 130872 |
| Year Published: | 2018 |
| Web of Science® Times Cited: | 51 |
| Deposited By: | Health Sciences |
| Deposited On: | 2019-02-19 |
| Last Modified: | 2019-03-25 |
| Downloads: | 81 View Download Statistics |
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