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Capillary gap flow cell as capillary-end electrochemical detector in flow-based analysis


Islam, MA and Lam, SC and Li, Y and Atia, MA and Mahbub, P and Nesterenko, PN and Paull, B and Macka, M, Capillary gap flow cell as capillary-end electrochemical detector in flow-based analysis, Electrochimica Acta, 303 pp. 85-93. ISSN 0013-4686 (2019) [Refereed Article]

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2019 Published by Elsevier Ltd.

DOI: doi:10.1016/j.electacta.2019.02.026


A gap flow cell (gap-FC) as a capillary-end electrochemical (EC) detector, incorporating exchangeable screen-printed electrodes, that facilitates adjustment of the gap distance between the capillary outlet and working electrode down to 30 μm was investigated. The analytical performance of the gap-FC was assessed in terms of detector response (current), the efficiency of EC conversion of ferrocyanide, and effective cell volume, as a function of flow rate and gap distance, within a range of 0.1-200 μL min-1 and 30-100 μm, respectively. As a result, an efficiency of EC conversion within the range of ∼1.5-11% (∼3-16 times higher than wall-jet FC), at an effective cell volume of ∼30-75 nL, was achieved. The gap-FC was applied as a liquid chromatography EC detector, coupled with standard and capillary format liquid chromatographs, where the analytical performance of gap-FC was compared with that of a UV detector. With the standard LC, the sensitivity for ascorbic acid, 2,3-dihydroxybenzoic acid and pyrocatechol, was greater than with the UV detector, with limits of detection (LODs) one order of magnitude lower for the gap-FC (0.10 μM, 0.09 μM, 0.19 μM, respectively, RSD 1.35-3.8%, n=9, linearity r2 ∼0.99 for concentration range 1-100 μM). LODs of test electroactive solutes using the gap-FC were ∼2 times lower than LODs reported in existing literature using standard EC detectors, including wall-jet and thin-layer FCs.

Item Details

Item Type:Refereed Article
Keywords:conversion efficiency, effective cell volume, flow-based analysis, gap distance, gap flow cell
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Electroanalytical chemistry
Objective Division:Manufacturing
Objective Group:Instrumentation
Objective Field:Scientific instruments
UTAS Author:Islam, MA (Mr Arif Islam)
UTAS Author:Lam, SC (Mr Shing Chung Lam)
UTAS Author:Li, Y (Mr Yan Li)
UTAS Author:Atia, MA (Mr Mostafa Atia Abuzeid)
UTAS Author:Mahbub, P (Dr Parvez Mahbub)
UTAS Author:Nesterenko, PN (Professor Pavel Nesterenko)
UTAS Author:Paull, B (Professor Brett Paull)
UTAS Author:Macka, M (Professor Mirek Macka)
ID Code:130820
Year Published:2019
Web of Science® Times Cited:4
Deposited By:Chemistry
Deposited On:2019-02-14
Last Modified:2022-08-23
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