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Probiotic Bacillus coagulans MTCC 5856 spores exhibit excellent in-vitro functional efficacy in simulated gastric survival, mucosal adhesion and immunomodulation

Citation

Shinde, T and Vemuri, R and Shastri, MD and Perera, AP and Tristram, S and Stanley, R and Eri, R, Probiotic Bacillus coagulans MTCC 5856 spores exhibit excellent in-vitro functional efficacy in simulated gastric survival, mucosal adhesion and immunomodulation, Journal of Functional Foods, 52 pp. 100-108. ISSN 1756-4646 (2019) [Refereed Article]

Copyright Statement

Copyright 2018 Elsevier Ltd.

DOI: doi:10.1016/j.jff.2018.10.031

Abstract

Probiotic Bacillus coagulans MTCC 5856 spores were evaluated in-vitro for their ability to survive simulated digestion, adhesion to colonic cells and immunomodulatory properties. The spores showed significant survival (92%) during simulated digestion and substantially adhered to the human colonic cells HT-29 (86%) and LS174T (81%) compared with the L. acidophilus control. They exerted marked immunomodulatory effects in HT-29 cells, by reducing IL-8 and increasing IL-10 secretion. Moreover, they exhibited pronounced differential immunomodulatory efficacy in response to lipopolysaccharide-induced inflammation under co-treatment (increased IL-10 and reduced IL-8) relative to post-treatment (reduced IL-8 with no IL-10 detection) in HT-29 cells. This observation supports the application of B. coagulans spores before or during the onset of inflammation to maximise the probiotic benefits in treating inflammatory bowel conditions. The results provide additional evidence of the probiotic properties of B. coagulans spores and support their incorporation into functional foods for improved gut health.

Item Details

Item Type:Refereed Article
Keywords:Probiotics
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
UTAS Author:Shinde, T (Ms Tanvi Shinde)
UTAS Author:Vemuri, R (Mr Ravichandra Vemuri)
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Perera, AP (Mrs Agampodi Perera)
UTAS Author:Tristram, S (Dr Stephen Tristram)
UTAS Author:Stanley, R (Professor Roger Stanley)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:130758
Year Published:2019
Web of Science® Times Cited:1
Deposited By:Health Sciences
Deposited On:2019-02-11
Last Modified:2019-07-31
Downloads:0

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