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The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility

Citation

Vemuri, R and Sylvia, KE and Klein, SL and Forster, SC and Plebanski, M and Eri, R and Flanagan, KL, The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility, Seminars in Immunopathology, 41, (2) pp. 265-275. ISSN 1863-2297 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Springer-Verlag GmbH Germany, part of Springer Nature

DOI: doi:10.1007/s00281-018-0716-7

Abstract

Sex differences in immunity are well described in the literature and thought to be mainly driven by sex hormones and sex-linked immune response genes. The gastrointestinal tract (GIT) is one of the largest immune organs in the body and contains multiple immune cells in the GIT-associated lymphoid tissue, Peyer's patches and elsewhere, which together have profound effects on local and systemic inflammation. The GIT is colonised with microbial communities composed of bacteria, fungi and viruses, collectively known as the GIT microbiota. The GIT microbiota drives multiple interactions locally with immune cells that regulate the homeostatic environment and systemically in diverse tissues. It is becoming evident that the microbiota differs between the sexes, both in animal models and in humans, and these sex differences often lead to sex-dependent changes in local GIT inflammation, systemic immunity and susceptibility to a range of inflammatory diseases. The sexually dimorphic microbiome has been termed the 'microgenderome'. Herein, we review the evidence for the microgenderome and contemplate the role it plays in driving sex differences in immunity and disease susceptibility. We further consider the impact that biological sex might play in the response to treatments aimed at manipulating the GIT microbiota, such as prebiotics, live biotherapeutics, (probiotics, synbiotics and bacteriotherapies) and faecal microbial transplant. These alternative therapies hold potential in the treatment of both psychological (e.g., anxiety, depression) and physiological (e.g., irritable bowel disease) disorders differentially affecting males and females.

Item Details

Item Type:Refereed Article
Keywords:adaptive immunity, innate immunity, sex differences, sex hormones, probiotics, faecal microbiota transplant, bacteriotherapy
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
UTAS Author:Vemuri, R (Mr Ravichandra Vemuri)
UTAS Author:Plebanski, M (Professor Magdalena Plebanski)
UTAS Author:Eri, R (Associate Professor Raj Eri)
UTAS Author:Flanagan, KL (Dr Katie Flanagan)
ID Code:130609
Year Published:2018
Web of Science® Times Cited:2
Deposited By:Medicine
Deposited On:2019-02-06
Last Modified:2019-04-08
Downloads:0

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